| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf68 | CASP14 | ENSP00000357764 | ENSP00000393417 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | 0.489 |
| C1orf68 | CDSN | ENSP00000357764 | ENSP00000365465 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Corneodesmosin; Important for the epidermal barrier integrity | 0.486 |
| C1orf68 | DSG1 | ENSP00000357764 | ENSP00000257192 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins | 0.505 |
| C1orf68 | DUOX2 | ENSP00000357764 | ENSP00000475084 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | 0.537 |
| C1orf68 | LCE4A | ENSP00000357764 | ENSP00000357766 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | 0.653 |
| C1orf68 | LCE6A | ENSP00000357764 | ENSP00000411070 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum | 0.547 |
| C1orf68 | SBSN | ENSP00000357764 | ENSP00000430242 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Suprabasin | 0.566 |
| C1orf68 | SERPINA12 | ENSP00000357764 | ENSP00000342109 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues; Serpin peptidase inhibitors | 0.487 |
| C1orf68 | TMEM14C | ENSP00000357764 | ENSP00000444561 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Transmembrane protein 14C; Required for normal heme biosynthesis | 0.533 |
| C1orf68 | TSPAN5 | ENSP00000357764 | ENSP00000307701 | Skin-specific protein 32; Chromosome 1 open reading frame 68 | Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins | 0.623 |
| CASP14 | C1orf68 | ENSP00000393417 | ENSP00000357764 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | Skin-specific protein 32; Chromosome 1 open reading frame 68 | 0.489 |
| CASP14 | CDSN | ENSP00000393417 | ENSP00000365465 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | Corneodesmosin; Important for the epidermal barrier integrity | 0.946 |
| CASP14 | DSG1 | ENSP00000393417 | ENSP00000257192 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins | 0.410 |
| CASP14 | LCE4A | ENSP00000393417 | ENSP00000357766 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | 0.900 |
| CASP14 | LCE6A | ENSP00000393417 | ENSP00000411070 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum | 0.902 |
| CASP14 | SBSN | ENSP00000393417 | ENSP00000430242 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | Suprabasin | 0.474 |
| CASP14 | TSPAN5 | ENSP00000393417 | ENSP00000307701 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins | 0.484 |
| CDSN | C1orf68 | ENSP00000365465 | ENSP00000357764 | Corneodesmosin; Important for the epidermal barrier integrity | Skin-specific protein 32; Chromosome 1 open reading frame 68 | 0.486 |
| CDSN | CASP14 | ENSP00000365465 | ENSP00000393417 | Corneodesmosin; Important for the epidermal barrier integrity | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA deg [...] | 0.946 |
| CDSN | DSG1 | ENSP00000365465 | ENSP00000257192 | Corneodesmosin; Important for the epidermal barrier integrity | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins | 0.738 |
