| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GPX2 | SEPP1 | ENSP00000374265 | ENSP00000420939 | Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors; Selenoproteins | Selenoprotein P; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.808 |
| GPX2 | SMCP | ENSP00000374265 | ENSP00000357754 | Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors; Selenoproteins | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.754 |
| GPX3 | SEPP1 | ENSP00000373477 | ENSP00000420939 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione; Selenoproteins | Selenoprotein P; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.837 |
| GPX3 | SMCP | ENSP00000373477 | ENSP00000357754 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione; Selenoproteins | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.628 |
| LCE1D | LCE1E | ENSP00000316737 | ENSP00000357759 | Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum | Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum | 0.998 |
| LCE1D | LCE3B | ENSP00000316737 | ENSP00000335358 | Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum | Late cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | 0.985 |
| LCE1D | SMCP | ENSP00000316737 | ENSP00000357754 | Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.686 |
| LCE1E | LCE1D | ENSP00000357759 | ENSP00000316737 | Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum | Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum | 0.998 |
| LCE1E | LCE3B | ENSP00000357759 | ENSP00000335358 | Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum | Late cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | 0.984 |
| LCE1E | SMCP | ENSP00000357759 | ENSP00000357754 | Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.686 |
| LCE3B | LCE1D | ENSP00000335358 | ENSP00000316737 | Late cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum | 0.985 |
| LCE3B | LCE1E | ENSP00000335358 | ENSP00000357759 | Late cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum | 0.984 |
| LCE3B | SMCP | ENSP00000335358 | ENSP00000357754 | Late cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.753 |
| ODF1 | PRM3 | ENSP00000285402 | ENSP00000325638 | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail; Small heat shock proteins | Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.477 |
| ODF1 | SMCP | ENSP00000285402 | ENSP00000357754 | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail; Small heat shock proteins | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.572 |
| ODF1 | TNP2 | ENSP00000285402 | ENSP00000325738 | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail; Small heat shock proteins | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction | 0.552 |
| PRM3 | ODF1 | ENSP00000325638 | ENSP00000285402 | Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail; Small heat shock proteins | 0.477 |
| PRM3 | SMCP | ENSP00000325638 | ENSP00000357754 | Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.776 |
| PRM3 | TNP2 | ENSP00000325638 | ENSP00000325738 | Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction | 0.839 |
| SEPP1 | GPX2 | ENSP00000420939 | ENSP00000374265 | Selenoprotein P; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors; Selenoproteins | 0.808 |
