| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf43 | CRCT1 | ENSP00000357507 | ENSP00000357779 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Cysteine rich C-terminal 1 | 0.700 |
| C1orf43 | S100A7A | ENSP00000357507 | ENSP00000357718 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.668 |
| CRCT1 | C1orf43 | ENSP00000357779 | ENSP00000357507 | Cysteine rich C-terminal 1 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | 0.700 |
| CRCT1 | IVL | ENSP00000357779 | ENSP00000357753 | Cysteine rich C-terminal 1 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | 0.613 |
| CRCT1 | S100A7A | ENSP00000357779 | ENSP00000357718 | Cysteine rich C-terminal 1 | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.694 |
| CRCT1 | SPRR4 | ENSP00000357779 | ENSP00000332163 | Cysteine rich C-terminal 1 | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family | 0.555 |
| FLG2 | IVL | ENSP00000373370 | ENSP00000357753 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | 0.538 |
| FLG2 | S100A7A | ENSP00000373370 | ENSP00000357718 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.649 |
| FLG2 | S100A7L2 | ENSP00000373370 | ENSP00000357714 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | S100 calcium binding protein A7 like 2; EF-hand domain containing | 0.608 |
| FLG2 | SPRR4 | ENSP00000373370 | ENSP00000332163 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family | 0.770 |
| IL36G | S100A12 | ENSP00000259205 | ENSP00000357726 | Interleukin-36 gamma; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinoc [...] | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leadin [...] | 0.400 |
| IL36G | S100A7A | ENSP00000259205 | ENSP00000357718 | Interleukin-36 gamma; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinoc [...] | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.555 |
| IVL | CRCT1 | ENSP00000357753 | ENSP00000357779 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Cysteine rich C-terminal 1 | 0.613 |
| IVL | FLG2 | ENSP00000357753 | ENSP00000373370 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | 0.538 |
| IVL | S100A7A | ENSP00000357753 | ENSP00000357718 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.529 |
| IVL | SPRR2G | ENSP00000357753 | ENSP00000357737 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity); Small proline rich proteins | 0.931 |
| IVL | SPRR4 | ENSP00000357753 | ENSP00000332163 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family | 0.569 |
| RASGEF1C | S100A7A | ENSP00000377037 | ENSP00000357718 | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.485 |
| S100A12 | IL36G | ENSP00000357726 | ENSP00000259205 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leadin [...] | Interleukin-36 gamma; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinoc [...] | 0.400 |
| S100A12 | S100A7A | ENSP00000357726 | ENSP00000357718 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leadin [...] | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.543 |
