| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANXA2 | S100A5 | ENSP00000346032 | ENSP00000357707 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | 0.475 |
| ANXA2 | S100A7 | ENSP00000346032 | ENSP00000357712 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family | S100 calcium binding protein A7; EF-hand domain containing | 0.923 |
| CNGA2 | S100A5 | ENSP00000328478 | ENSP00000357707 | Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | 0.476 |
| DFNA5 | S100A5 | ENSP00000339587 | ENSP00000357707 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | 0.460 |
| INTS10 | S100A5 | ENSP00000381064 | ENSP00000357707 | Integrator complex subunit 10; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | 0.426 |
| LRRC3B | S100A5 | ENSP00000379880 | ENSP00000357707 | Leucine-rich repeat-containing protein 3B; Leucine rich repeat containing 3B | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | 0.500 |
| OR5A1 | S100A5 | ENSP00000303096 | ENSP00000357707 | Olfactory receptor 5A1; Odorant receptor; Olfactory receptors, family 5 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | 0.436 |
| S100A14 | S100A5 | ENSP00000357691 | ENSP00000357707 | Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium; S100 calcium binding proteins | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | 0.466 |
| S100A14 | S100A7 | ENSP00000357691 | ENSP00000357712 | Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium; S100 calcium binding proteins | S100 calcium binding protein A7; EF-hand domain containing | 0.506 |
| S100A5 | ANXA2 | ENSP00000357707 | ENSP00000346032 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family | 0.475 |
| S100A5 | CNGA2 | ENSP00000357707 | ENSP00000328478 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily | 0.476 |
| S100A5 | DFNA5 | ENSP00000357707 | ENSP00000339587 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.460 |
| S100A5 | INTS10 | ENSP00000357707 | ENSP00000381064 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Integrator complex subunit 10; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex | 0.426 |
| S100A5 | LRRC3B | ENSP00000357707 | ENSP00000379880 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Leucine-rich repeat-containing protein 3B; Leucine rich repeat containing 3B | 0.500 |
| S100A5 | OR5A1 | ENSP00000357707 | ENSP00000303096 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Olfactory receptor 5A1; Odorant receptor; Olfactory receptors, family 5 | 0.436 |
| S100A5 | S100A14 | ENSP00000357707 | ENSP00000357691 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium; S100 calcium binding proteins | 0.466 |
| S100A5 | S100A7 | ENSP00000357707 | ENSP00000357712 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | S100 calcium binding protein A7; EF-hand domain containing | 0.566 |
| S100A5 | S100G | ENSP00000357707 | ENSP00000369547 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | S100 calcium binding protein G; Belongs to the S-100 family | 0.440 |
| S100A5 | SUSD4 | ENSP00000357707 | ENSP00000344219 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; EF-hand domain containing | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways; Sushi domain containing | 0.459 |
| S100A7 | ANXA2 | ENSP00000357712 | ENSP00000346032 | S100 calcium binding protein A7; EF-hand domain containing | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family | 0.923 |
