| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FLG2 | S100A3 | ENSP00000373370 | ENSP00000357702 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins | 0.720 |
| FLG2 | S100A7 | ENSP00000373370 | ENSP00000357712 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | S100 calcium binding protein A7; EF-hand domain containing | 0.636 |
| FLG2 | SPRR1A | ENSP00000373370 | ENSP00000357751 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins | 0.542 |
| FLG2 | SPRR1B | ENSP00000373370 | ENSP00000306461 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family | 0.580 |
| FLG2 | SPRR4 | ENSP00000373370 | ENSP00000332163 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family | 0.770 |
| S100A1 | S100A2 | ENSP00000292169 | ENSP00000357697 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity; Belongs to the S-100 family | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing | 0.794 |
| S100A1 | S100A3 | ENSP00000292169 | ENSP00000357702 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity; Belongs to the S-100 family | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins | 0.785 |
| S100A1 | S100A7 | ENSP00000292169 | ENSP00000357712 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity; Belongs to the S-100 family | S100 calcium binding protein A7; EF-hand domain containing | 0.640 |
| S100A1 | S100Z | ENSP00000292169 | ENSP00000320430 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity; Belongs to the S-100 family | S100 calcium binding protein Z; EF-hand domain containing | 0.816 |
| S100A1 | SPRR1B | ENSP00000292169 | ENSP00000306461 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity; Belongs to the S-100 family | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family | 0.438 |
| S100A10 | S100A3 | ENSP00000357801 | ENSP00000357702 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase; Belongs to the S-100 family | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins | 0.915 |
| S100A10 | S100A7 | ENSP00000357801 | ENSP00000357712 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase; Belongs to the S-100 family | S100 calcium binding protein A7; EF-hand domain containing | 0.532 |
| S100A10 | S100Z | ENSP00000357801 | ENSP00000320430 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase; Belongs to the S-100 family | S100 calcium binding protein Z; EF-hand domain containing | 0.811 |
| S100A10 | SPRR1A | ENSP00000357801 | ENSP00000357751 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase; Belongs to the S-100 family | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins | 0.641 |
| S100A10 | SPRR1B | ENSP00000357801 | ENSP00000306461 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase; Belongs to the S-100 family | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family | 0.539 |
| S100A2 | S100A1 | ENSP00000357697 | ENSP00000292169 | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity; Belongs to the S-100 family | 0.794 |
| S100A2 | S100A3 | ENSP00000357697 | ENSP00000357702 | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins | 0.863 |
| S100A2 | S100A7 | ENSP00000357697 | ENSP00000357712 | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing | S100 calcium binding protein A7; EF-hand domain containing | 0.702 |
| S100A2 | SPRR1A | ENSP00000357697 | ENSP00000357751 | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins | 0.559 |
| S100A2 | SPRR1B | ENSP00000357697 | ENSP00000306461 | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family | 0.633 |
