| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNL2 | WISP3 | ENSP00000383611 | ENSP00000357655 | Cyclin-L2; Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors; Cyclins | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.663 |
| CDH1 | RHOC | ENSP00000261769 | ENSP00000285735 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | 0.724 |
| CDH1 | WISP3 | ENSP00000261769 | ENSP00000357655 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.656 |
| CDH1 | WNT1 | ENSP00000261769 | ENSP00000293549 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development | 0.596 |
| CDH1 | ZEB1 | ENSP00000261769 | ENSP00000354487 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5’-CANNTG [...] | 0.997 |
| COL10A1 | WISP3 | ENSP00000327368 | ENSP00000357655 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.526 |
| MRAP2 | WISP3 | ENSP00000257776 | ENSP00000357655 | Melanocortin-2 receptor accessory protein 2; Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R- competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.502 |
| RHOC | CDH1 | ENSP00000285735 | ENSP00000261769 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | 0.724 |
| RHOC | WISP3 | ENSP00000285735 | ENSP00000357655 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.530 |
| RHOC | WNT1 | ENSP00000285735 | ENSP00000293549 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development | 0.532 |
| RHOC | ZEB1 | ENSP00000285735 | ENSP00000354487 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5’-CANNTG [...] | 0.412 |
| SNX9 | WISP3 | ENSP00000376024 | ENSP00000357655 | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promot [...] | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.622 |
| SNX9 | WNT1 | ENSP00000376024 | ENSP00000293549 | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promot [...] | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development | 0.441 |
| TRAPPC2 | WISP3 | ENSP00000392495 | ENSP00000357655 | Trafficking protein particle complex subunit 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. Sedlin subfamily | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.555 |
| TRAPPC2P1 | WISP3 | ENSP00000469888 | ENSP00000357655 | Trafficking protein particle complex 2 pseudogene 1 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | 0.577 |
| WISP3 | CCNL2 | ENSP00000357655 | ENSP00000383611 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | Cyclin-L2; Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors; Cyclins | 0.663 |
| WISP3 | CDH1 | ENSP00000357655 | ENSP00000261769 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | 0.656 |
| WISP3 | COL10A1 | ENSP00000357655 | ENSP00000327368 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens | 0.526 |
| WISP3 | MRAP2 | ENSP00000357655 | ENSP00000257776 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | Melanocortin-2 receptor accessory protein 2; Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R- competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo | 0.502 |
| WISP3 | RHOC | ENSP00000357655 | ENSP00000285735 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | 0.530 |
