| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EBF3 | FBXO31 | ENSP00000357637 | ENSP00000310841 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor; Belongs to the FBXO31 family | 0.481 |
| EBF3 | MEN1 | ENSP00000357637 | ENSP00000337088 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] | 0.522 |
| EBF3 | MT-ND2 | ENSP00000357637 | ENSP00000355046 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity); NADH-ubiquinone oxidoreductase core subunits | 0.543 |
| EBF3 | OSR2 | ENSP00000357637 | ENSP00000414657 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | Protein odd-skipped-related 2; Odd-skipped related transciption factor 2; Zinc fingers C2H2-type | 0.420 |
| EBF3 | SKOR2 | ENSP00000357637 | ENSP00000483333 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | 0.459 |
| EBF3 | TLR4 | ENSP00000357637 | ENSP00000363089 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with T [...] | 0.401 |
| EBF3 | TMTC1 | ENSP00000357637 | ENSP00000442046 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | Transmembrane and tetratricopeptide repeat containing 1 | 0.437 |
| EBF3 | UFD1L | ENSP00000357637 | ENSP00000263202 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...] | 0.439 |
| EBF3 | ZNF423 | ENSP00000357637 | ENSP00000455426 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmenta [...] | 0.513 |
| FBXO31 | EBF3 | ENSP00000310841 | ENSP00000357637 | F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor; Belongs to the FBXO31 family | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.481 |
| MEN1 | EBF3 | ENSP00000337088 | ENSP00000357637 | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.522 |
| MT-ND2 | EBF3 | ENSP00000355046 | ENSP00000357637 | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity); NADH-ubiquinone oxidoreductase core subunits | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.543 |
| OSR2 | EBF3 | ENSP00000414657 | ENSP00000357637 | Protein odd-skipped-related 2; Odd-skipped related transciption factor 2; Zinc fingers C2H2-type | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.420 |
| SKOR2 | EBF3 | ENSP00000483333 | ENSP00000357637 | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.459 |
| TLR4 | EBF3 | ENSP00000363089 | ENSP00000357637 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with T [...] | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.401 |
| TMTC1 | EBF3 | ENSP00000442046 | ENSP00000357637 | Transmembrane and tetratricopeptide repeat containing 1 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.437 |
| TMTC1 | ZNF423 | ENSP00000442046 | ENSP00000455426 | Transmembrane and tetratricopeptide repeat containing 1 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmenta [...] | 0.442 |
| UFD1L | EBF3 | ENSP00000263202 | ENSP00000357637 | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...] | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.439 |
| ZNF423 | EBF3 | ENSP00000455426 | ENSP00000357637 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmenta [...] | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family | 0.513 |
| ZNF423 | TMTC1 | ENSP00000455426 | ENSP00000442046 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmenta [...] | Transmembrane and tetratricopeptide repeat containing 1 | 0.442 |
