node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY2 | FAM26F | ENSP00000303570 | ENSP00000357594 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | 0.612 |
ANKMY2 | HEXB | ENSP00000303570 | ENSP00000261416 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.628 |
ANKMY2 | LMAN2L | ENSP00000303570 | ENSP00000366280 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | VIP36-like protein; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 | 0.603 |
ANKMY2 | NMT1 | ENSP00000303570 | ENSP00000468424 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.619 |
ANKMY2 | PHF20L1 | ENSP00000303570 | ENSP00000378784 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | PHD finger protein 20 like 1 | 0.636 |
ANKMY2 | SLC8B1 | ENSP00000303570 | ENSP00000447091 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion- calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion- acts by mediating efflux of ca [...] | 0.527 |
ANKMY2 | SPPL2A | ENSP00000303570 | ENSP00000261854 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...] | 0.661 |
ANKMY2 | TSPAN13 | ENSP00000303570 | ENSP00000262067 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Tetraspanin-13; Tetraspanin 13; Tetraspanins | 0.775 |
ANKMY2 | USP25 | ENSP00000303570 | ENSP00000383044 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains; Belongs to the peptidase C19 family | 0.529 |
FAM26F | ANKMY2 | ENSP00000357594 | ENSP00000303570 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | 0.612 |
FAM26F | HEXB | ENSP00000357594 | ENSP00000261416 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.677 |
FAM26F | IRF5 | ENSP00000357594 | ENSP00000349770 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Interferon regulatory factor 5; Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling; Belongs to the IRF family | 0.612 |
FAM26F | LMAN2L | ENSP00000357594 | ENSP00000366280 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | VIP36-like protein; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 | 0.545 |
FAM26F | NMT1 | ENSP00000357594 | ENSP00000468424 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.663 |
FAM26F | PHF20L1 | ENSP00000357594 | ENSP00000378784 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | PHD finger protein 20 like 1 | 0.705 |
FAM26F | SLC8B1 | ENSP00000357594 | ENSP00000447091 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion- calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion- acts by mediating efflux of ca [...] | 0.529 |
FAM26F | SPPL2A | ENSP00000357594 | ENSP00000261854 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...] | 0.566 |
FAM26F | TSPAN13 | ENSP00000357594 | ENSP00000262067 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Tetraspanin-13; Tetraspanin 13; Tetraspanins | 0.544 |
FAM26F | USP25 | ENSP00000357594 | ENSP00000383044 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains; Belongs to the peptidase C19 family | 0.519 |
HEXB | ANKMY2 | ENSP00000261416 | ENSP00000303570 | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | 0.628 |