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  • 11.0 [archived version]
STRINGSTRING
MINPP1 MINPP1 ITPKB ITPKB ITPKC ITPKC IPMK IPMK ITPK1 ITPK1 ITPKA ITPKA INPP5A INPP5A INPP1 INPP1 INPP5J INPP5J INPP4B INPP4B INPP4A INPP4A
"INPP5A" - Type I inositol 1,4,5-trisphosphate 5-phosphatase in Homo sapiens
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase; Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction; Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family (412 aa)    
Predicted Functional Partners:
ITPKA
Inositol-trisphosphate 3-kinase A; Belongs to the inositol phosphokinase (IPK) family (461 aa)
     
 
  0.962
IPMK
Inositol polyphosphate multikinase; Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (416 aa)
     
 
  0.952
INPP4A
Type I inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate (977 aa)
     
 
  0.948
ITPKC
Inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate; Belongs to the inositol phosphokinase (IPK) family (683 aa)
     
 
  0.948
INPP5J
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity); Phosphoinositide phosphatases (1006 aa)
     
 
  0.948
ITPKB
Inositol-trisphosphate 3-kinase B (946 aa)
     
 
  0.944
MINPP1
Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity); Belongs [...] (487 aa)
         
  0.939
INPP4B
Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate (924 aa)
     
 
  0.932
ITPK1
Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] (414 aa)
         
  0.918
INPP1
Inositol polyphosphate-1-phosphatase; Belongs to the inositol monophosphatase superfamily (399 aa)
     
 
  0.917
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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