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  • 11.0 [archived version]
STRINGSTRING
NPIPB11 NPIPB11 ERMARD ERMARD C19orf81 C19orf81 DNAH2 DNAH2 CFAP46 CFAP46 CXorf58 CXorf58 DNAH10 DNAH10 RNF115 RNF115 PACRG PACRG C12orf55 C12orf55 CFAP221 CFAP221
"CFAP46" - Cilia- and flagella-associated protein 46 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CFAP46Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement; Cilia and flagella associated (2715 aa)    
Predicted Functional Partners:
C12orf55
Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella (3096 aa)
     
   
  0.813
DNAH10
Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain (4471 aa)
     
   
  0.775
CFAP221
Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis; Cilia and flagella associated (840 aa)
     
   
  0.758
ERMARD
Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development (678 aa)
           
  0.747
RNF115
E3 ubiquitin-protein ligase RNF115; E3 ubiquitin-protein ligase that mediates E2-dependent, ’Lys-48’- and/or ’Lys-63’-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4; Ring finger proteins (304 aa)
           
  0.746
PACRG
Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease; Armadillo-like helical domain containing (296 aa)
           
  0.732
CXorf58
Putative uncharacterized protein CXorf58; Chromosome X open reading frame 58 (332 aa)
     
   
  0.707
C19orf81
Putative uncharacterized protein C19orf81; Chromosome 19 open reading frame 81 (198 aa)
           
  0.701
NPIPB11
Nuclear pore complex interacting protein family member B11 (1161 aa)
           
  0.675
DNAH2
Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal (4427 aa)
     
   
  0.645
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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