VENTX protein (human) - STRING database

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Score

VENTX

Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes (258 aa)

Predicted Functional Partners:

AES

0.875

TLE4

0.859

DPRX

0.758

ARGFX

0.743

DUXA

0.722

CHRD

0.700

UTF1

0.680

WNT8A

0.652

ANXA11

0.629

BMP4

0.570

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AES	TLE4	ENSP00000221561	ENSP00000365720	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	Transducin-like enhancer protein 4; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity); Belongs to the WD repeat Groucho/TLE family	0.985
AES	VENTX	ENSP00000221561	ENSP00000357556	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes	0.875
ANXA11	ARGFX	ENSP00000398610	ENSP00000335578	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family	Arginine-fifty homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	0.428
ANXA11	DPRX	ENSP00000398610	ENSP00000365838	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family	Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	0.512
ANXA11	DUXA	ENSP00000398610	ENSP00000452398	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family	Double homeobox protein A; Putative transcription factor; PRD class homeoboxes and pseudogenes	0.668
ANXA11	VENTX	ENSP00000398610	ENSP00000357556	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family	Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes	0.629
ARGFX	ANXA11	ENSP00000335578	ENSP00000398610	Arginine-fifty homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family	0.428
ARGFX	DPRX	ENSP00000335578	ENSP00000365838	Arginine-fifty homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	0.457
ARGFX	DUXA	ENSP00000335578	ENSP00000452398	Arginine-fifty homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	Double homeobox protein A; Putative transcription factor; PRD class homeoboxes and pseudogenes	0.797
ARGFX	VENTX	ENSP00000335578	ENSP00000357556	Arginine-fifty homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes	0.743
BMP4	CHRD	ENSP00000245451	ENSP00000204604	Bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity); Bone morphogenetic proteins	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity)	0.994
BMP4	VENTX	ENSP00000245451	ENSP00000357556	Bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity); Bone morphogenetic proteins	Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes	0.570
BMP4	WNT8A	ENSP00000245451	ENSP00000426653	Bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity); Bone morphogenetic proteins	Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus	0.760
CHRD	BMP4	ENSP00000204604	ENSP00000245451	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity)	Bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity); Bone morphogenetic proteins	0.994
CHRD	VENTX	ENSP00000204604	ENSP00000357556	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity)	Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes	0.700
CHRD	WNT8A	ENSP00000204604	ENSP00000426653	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity)	Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus	0.743
DPRX	ANXA11	ENSP00000365838	ENSP00000398610	Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family	0.512
DPRX	ARGFX	ENSP00000365838	ENSP00000335578	Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	Arginine-fifty homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	0.457
DPRX	VENTX	ENSP00000365838	ENSP00000357556	Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes	Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes	0.758
DUXA	ANXA11	ENSP00000452398	ENSP00000398610	Double homeobox protein A; Putative transcription factor; PRD class homeoboxes and pseudogenes	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family	0.668

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