node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf43 | C1orf43 | ENSP00000340644 | ENSP00000357507 | Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | 0.724 |
C15orf43 | CABP2 | ENSP00000340644 | ENSP00000294288 | Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | Calcium binding protein 2; EF-hand domain containing | 0.695 |
C15orf43 | RIBC1 | ENSP00000340644 | ENSP00000364476 | Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family | 0.802 |
C1orf189 | C1orf43 | ENSP00000357511 | ENSP00000357507 | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | 0.588 |
C1orf43 | C15orf43 | ENSP00000357507 | ENSP00000340644 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | 0.724 |
C1orf43 | C1orf189 | ENSP00000357507 | ENSP00000357511 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189 | 0.588 |
C1orf43 | CABP2 | ENSP00000357507 | ENSP00000294288 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Calcium binding protein 2; EF-hand domain containing | 0.681 |
C1orf43 | CHMP2A | ENSP00000357507 | ENSP00000469240 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.645 |
C1orf43 | CRCT1 | ENSP00000357507 | ENSP00000357779 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Cysteine rich C-terminal 1 | 0.700 |
C1orf43 | EMC7 | ENSP00000357507 | ENSP00000256545 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | ER membrane protein complex subunit 7 | 0.740 |
C1orf43 | PSMB4 | ENSP00000357507 | ENSP00000290541 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] | 0.613 |
C1orf43 | RIBC1 | ENSP00000357507 | ENSP00000364476 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family | 0.726 |
C1orf43 | S100A7A | ENSP00000357507 | ENSP00000357718 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing | 0.668 |
C1orf43 | SNRPD3 | ENSP00000357507 | ENSP00000215829 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.579 |
CABP2 | C15orf43 | ENSP00000294288 | ENSP00000340644 | Calcium binding protein 2; EF-hand domain containing | Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | 0.695 |
CABP2 | C1orf43 | ENSP00000294288 | ENSP00000357507 | Calcium binding protein 2; EF-hand domain containing | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | 0.681 |
CABP2 | RIBC1 | ENSP00000294288 | ENSP00000364476 | Calcium binding protein 2; EF-hand domain containing | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family | 0.711 |
CHMP2A | C1orf43 | ENSP00000469240 | ENSP00000357507 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 | 0.645 |
CHMP2A | EMC7 | ENSP00000469240 | ENSP00000256545 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | ER membrane protein complex subunit 7 | 0.769 |
CHMP2A | PSMB4 | ENSP00000469240 | ENSP00000290541 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] | 0.600 |