node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC6 | CEP85L | ENSP00000263102 | ENSP00000357474 | Coiled-coil domain containing 6 | Centrosomal protein 85 like; Belongs to the CEP85 family | 0.687 |
CCDC6 | GOPC | ENSP00000263102 | ENSP00000357484 | Coiled-coil domain containing 6 | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes; PDZ domain containing | 0.572 |
CCDC6 | LRIG3 | ENSP00000263102 | ENSP00000326759 | Coiled-coil domain containing 6 | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity); I-set domain containing | 0.692 |
CCDC6 | ROS1 | ENSP00000263102 | ENSP00000357494 | Coiled-coil domain containing 6 | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] | 0.660 |
CCDC6 | SLC34A2 | ENSP00000263102 | ENSP00000371483 | Coiled-coil domain containing 6 | Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs’ alveoli; Belongs to the SLC34A transporter family | 0.689 |
CCDC6 | TFG | ENSP00000263102 | ENSP00000240851 | Coiled-coil domain containing 6 | Protein TFG; Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules | 0.410 |
CEP85L | CCDC6 | ENSP00000357474 | ENSP00000263102 | Centrosomal protein 85 like; Belongs to the CEP85 family | Coiled-coil domain containing 6 | 0.687 |
CEP85L | FAM133B | ENSP00000357474 | ENSP00000398401 | Centrosomal protein 85 like; Belongs to the CEP85 family | Protein FAM133B; Family with sequence similarity 133 member B | 0.535 |
CEP85L | GOPC | ENSP00000357474 | ENSP00000357484 | Centrosomal protein 85 like; Belongs to the CEP85 family | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes; PDZ domain containing | 0.562 |
CEP85L | LRIG3 | ENSP00000357474 | ENSP00000326759 | Centrosomal protein 85 like; Belongs to the CEP85 family | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity); I-set domain containing | 0.531 |
CEP85L | LRRC3C | ENSP00000357474 | ENSP00000367157 | Centrosomal protein 85 like; Belongs to the CEP85 family | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.519 |
CEP85L | NT5DC1 | ENSP00000357474 | ENSP00000326858 | Centrosomal protein 85 like; Belongs to the CEP85 family | 5’-nucleotidase domain containing 1 | 0.511 |
CEP85L | ROS1 | ENSP00000357474 | ENSP00000357494 | Centrosomal protein 85 like; Belongs to the CEP85 family | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] | 0.508 |
CEP85L | SLC34A2 | ENSP00000357474 | ENSP00000371483 | Centrosomal protein 85 like; Belongs to the CEP85 family | Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs’ alveoli; Belongs to the SLC34A transporter family | 0.559 |
CEP85L | SLC35F1 | ENSP00000357474 | ENSP00000353557 | Centrosomal protein 85 like; Belongs to the CEP85 family | Solute carrier family 35 member F1; Putative solute transporter | 0.709 |
CEP85L | TFG | ENSP00000357474 | ENSP00000240851 | Centrosomal protein 85 like; Belongs to the CEP85 family | Protein TFG; Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules | 0.494 |
FAM133B | CEP85L | ENSP00000398401 | ENSP00000357474 | Protein FAM133B; Family with sequence similarity 133 member B | Centrosomal protein 85 like; Belongs to the CEP85 family | 0.535 |
GOPC | CCDC6 | ENSP00000357484 | ENSP00000263102 | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes; PDZ domain containing | Coiled-coil domain containing 6 | 0.572 |
GOPC | CEP85L | ENSP00000357484 | ENSP00000357474 | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes; PDZ domain containing | Centrosomal protein 85 like; Belongs to the CEP85 family | 0.562 |
GOPC | LRIG3 | ENSP00000357484 | ENSP00000326759 | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes; PDZ domain containing | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity); I-set domain containing | 0.600 |