• Version:
  • 11.0 [archived version]
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LRIG3 LRIG3 SLC34A2 SLC34A2 ROS1 ROS1 GOPC GOPC TFG TFG CCDC6 CCDC6 LRRC3C LRRC3C CEP85L CEP85L SLC35F1 SLC35F1 FAM133B FAM133B NT5DC1 NT5DC1
"CEP85L" - Centrosomal protein 85 like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CEP85LCentrosomal protein 85 like; Belongs to the CEP85 family (808 aa)    
Predicted Functional Partners:
SLC35F1
Solute carrier family 35 member F1; Putative solute transporter (408 aa)
           
  0.709
CCDC6
Coiled-coil domain containing 6 (474 aa)
     
   
  0.687
GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes; PDZ domain containing (462 aa)
     
   
  0.562
SLC34A2
Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs’ alveoli; Belongs to the SLC34A transporter family (690 aa)
           
  0.559
FAM133B
Protein FAM133B; Family with sequence similarity 133 member B (247 aa)
           
  0.535
LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity); I-set domain containing (1119 aa)
           
  0.531
LRRC3C
Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C (275 aa)
           
  0.519
NT5DC1
5’-nucleotidase domain containing 1 (455 aa)
           
  0.511
ROS1
Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] (2347 aa)
           
  0.508
TFG
Protein TFG; Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (400 aa)
           
  0.494
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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