PBXIP1 protein (human) - STRING database

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PBXIP1

Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (731 aa)

Predicted Functional Partners:

GMCL1

0.686

NUP210L

0.640

DCST2

0.639

CCDC30

0.602

DCST1

0.580

TMEM63B

0.571

TCTE1

0.563

TOM1L2

0.548

LRRC48

0.547

CAPN11

0.543

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPN11	DCST1	ENSP00000381758	ENSP00000295542	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	0.515
CAPN11	LRRC48	ENSP00000381758	ENSP00000382140	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	0.479
CAPN11	NUP210L	ENSP00000381758	ENSP00000357547	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family	0.520
CAPN11	PBXIP1	ENSP00000381758	ENSP00000357448	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling	0.543
CAPN11	TCTE1	ENSP00000381758	ENSP00000360560	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	T-complex-associated-testis-expressed 1; Dynein regulatory complex	0.500
CAPN11	TMEM63B	ENSP00000381758	ENSP00000259746	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	0.517
CAPN11	TOM1L2	ENSP00000381758	ENSP00000368818	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling	0.449
CCDC30	PBXIP1	ENSP00000339280	ENSP00000357448	Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling	0.602
DCST1	CAPN11	ENSP00000295542	ENSP00000381758	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	0.515
DCST1	LRRC48	ENSP00000295542	ENSP00000382140	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	0.586
DCST1	NUP210L	ENSP00000295542	ENSP00000357547	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family	0.632
DCST1	PBXIP1	ENSP00000295542	ENSP00000357448	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling	0.580
DCST1	TCTE1	ENSP00000295542	ENSP00000360560	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	T-complex-associated-testis-expressed 1; Dynein regulatory complex	0.604
DCST1	TMEM63B	ENSP00000295542	ENSP00000259746	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	0.610
DCST1	TOM1L2	ENSP00000295542	ENSP00000368818	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling	0.538
DCST2	PBXIP1	ENSP00000357409	ENSP00000357448	DC-STAMP domain containing 2	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling	0.639
GMCL1	PBXIP1	ENSP00000282570	ENSP00000357448	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity); BTB domain containing	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling	0.686
LRRC48	CAPN11	ENSP00000382140	ENSP00000381758	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family	0.479
LRRC48	DCST1	ENSP00000382140	ENSP00000295542	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	0.586
LRRC48	NUP210L	ENSP00000382140	ENSP00000357547	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family	0.600

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