node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM15 | DCST2 | ENSP00000349436 | ENSP00000357409 | Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. [...] | DC-STAMP domain containing 2 | 0.508 |
ADAM15 | PBXIP1 | ENSP00000349436 | ENSP00000357448 | Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. [...] | Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling | 0.482 |
COBLL1 | DCST2 | ENSP00000341360 | ENSP00000357409 | Cordon-bleu WH2 repeat protein like 1 | DC-STAMP domain containing 2 | 0.621 |
COBLL1 | GRB14 | ENSP00000341360 | ENSP00000263915 | Cordon-bleu WH2 repeat protein like 1 | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal; Pleckstrin homology domain containing | 0.722 |
DCST2 | ADAM15 | ENSP00000357409 | ENSP00000349436 | DC-STAMP domain containing 2 | Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. [...] | 0.508 |
DCST2 | COBLL1 | ENSP00000357409 | ENSP00000341360 | DC-STAMP domain containing 2 | Cordon-bleu WH2 repeat protein like 1 | 0.621 |
DCST2 | GORAB | ENSP00000357409 | ENSP00000356737 | DC-STAMP domain containing 2 | Golgin, RAB6 interacting | 0.590 |
DCST2 | GRB14 | ENSP00000357409 | ENSP00000263915 | DC-STAMP domain containing 2 | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal; Pleckstrin homology domain containing | 0.553 |
DCST2 | NKX2-6 | ENSP00000357409 | ENSP00000320089 | DC-STAMP domain containing 2 | Homeobox protein Nkx-2.6; Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development; NKL subclass homeoboxes and pseudogenes | 0.520 |
DCST2 | PBXIP1 | ENSP00000357409 | ENSP00000357448 | DC-STAMP domain containing 2 | Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling | 0.639 |
DCST2 | SNX10 | ENSP00000357409 | ENSP00000395474 | DC-STAMP domain containing 2 | Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption | 0.575 |
DCST2 | STXBP6 | ENSP00000357409 | ENSP00000324302 | DC-STAMP domain containing 2 | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis | 0.487 |
DCST2 | SUMF1 | ENSP00000357409 | ENSP00000272902 | DC-STAMP domain containing 2 | Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family | 0.485 |
DCST2 | WARS2 | ENSP00000357409 | ENSP00000235521 | DC-STAMP domain containing 2 | Tryptophan--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis | 0.542 |
GORAB | DCST2 | ENSP00000356737 | ENSP00000357409 | Golgin, RAB6 interacting | DC-STAMP domain containing 2 | 0.590 |
GORAB | NKX2-6 | ENSP00000356737 | ENSP00000320089 | Golgin, RAB6 interacting | Homeobox protein Nkx-2.6; Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development; NKL subclass homeoboxes and pseudogenes | 0.453 |
GORAB | SNX10 | ENSP00000356737 | ENSP00000395474 | Golgin, RAB6 interacting | Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption | 0.496 |
GRB14 | COBLL1 | ENSP00000263915 | ENSP00000341360 | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal; Pleckstrin homology domain containing | Cordon-bleu WH2 repeat protein like 1 | 0.722 |
GRB14 | DCST2 | ENSP00000263915 | ENSP00000357409 | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal; Pleckstrin homology domain containing | DC-STAMP domain containing 2 | 0.553 |
NKX2-6 | DCST2 | ENSP00000320089 | ENSP00000357409 | Homeobox protein Nkx-2.6; Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development; NKL subclass homeoboxes and pseudogenes | DC-STAMP domain containing 2 | 0.520 |