| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAD9 | YY1AP1 | ENSP00000312618 | ENSP00000357323 | Acyl-CoA dehydrogenase family member 9, mitochondrial; Required for mitochondrial complex I assembly. Has a dehydrogenase activity on palmitoyl-CoA (C16-0) and stearoyl-CoA (C18-0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo. Has little activity on octanoyl-CoA (C8-0), butyryl-CoA (C4-0) or isovaleryl-CoA (5-0); Belongs to the acyl-CoA dehydrogenase family | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.635 |
| ASH1L | YY1AP1 | ENSP00000376204 | ENSP00000357323 | Histone-lysine N-methyltransferase ASH1L; Histone methyltransferase specifically methylating ’Lys- 36’ of histone H3 (H3K36me); Bromodomain containing | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.906 |
| CLEC3A | YY1AP1 | ENSP00000299642 | ENSP00000357323 | C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin; C-type lectin domain containing | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.519 |
| CLEC3A | ZNF579 | ENSP00000299642 | ENSP00000320188 | C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin; C-type lectin domain containing | Zinc finger protein 579; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.512 |
| NEUROG3 | YY1AP1 | ENSP00000242462 | ENSP00000357323 | Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity); Basic helix-loop-helix proteins | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.519 |
| NEUROG3 | ZNF496 | ENSP00000242462 | ENSP00000294753 | Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity); Basic helix-loop-helix proteins | Zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.553 |
| SS18L2 | YY1AP1 | ENSP00000401115 | ENSP00000357323 | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.547 |
| SULT2B1 | YY1AP1 | ENSP00000201586 | ENSP00000357323 | Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...] | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.501 |
| YY1 | YY1AP1 | ENSP00000262238 | ENSP00000357323 | Transcriptional repressor protein YY1; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activa [...] | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.688 |
| YY1AP1 | ACAD9 | ENSP00000357323 | ENSP00000312618 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Acyl-CoA dehydrogenase family member 9, mitochondrial; Required for mitochondrial complex I assembly. Has a dehydrogenase activity on palmitoyl-CoA (C16-0) and stearoyl-CoA (C18-0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo. Has little activity on octanoyl-CoA (C8-0), butyryl-CoA (C4-0) or isovaleryl-CoA (5-0); Belongs to the acyl-CoA dehydrogenase family | 0.635 |
| YY1AP1 | ASH1L | ENSP00000357323 | ENSP00000376204 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Histone-lysine N-methyltransferase ASH1L; Histone methyltransferase specifically methylating ’Lys- 36’ of histone H3 (H3K36me); Bromodomain containing | 0.906 |
| YY1AP1 | CLEC3A | ENSP00000357323 | ENSP00000299642 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin; C-type lectin domain containing | 0.519 |
| YY1AP1 | NEUROG3 | ENSP00000357323 | ENSP00000242462 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity); Basic helix-loop-helix proteins | 0.519 |
| YY1AP1 | SS18L2 | ENSP00000357323 | ENSP00000401115 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family | 0.547 |
| YY1AP1 | SULT2B1 | ENSP00000357323 | ENSP00000201586 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...] | 0.501 |
| YY1AP1 | YY1 | ENSP00000357323 | ENSP00000262238 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Transcriptional repressor protein YY1; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activa [...] | 0.688 |
| YY1AP1 | ZMYM4 | ENSP00000357323 | ENSP00000322915 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization; Zinc fingers MYM-type | 0.646 |
| YY1AP1 | ZNF496 | ENSP00000357323 | ENSP00000294753 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.799 |
| YY1AP1 | ZNF579 | ENSP00000357323 | ENSP00000320188 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | Zinc finger protein 579; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.537 |
| ZMYM4 | YY1AP1 | ENSP00000322915 | ENSP00000357323 | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization; Zinc fingers MYM-type | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation | 0.646 |
