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STRINGSTRING
ANKRD7 ANKRD7 SLC25A51 SLC25A51 RIMBP3C RIMBP3C RIMBP3B RIMBP3B ALS2CR11 ALS2CR11 ARMC12 ARMC12 FSCB FSCB C19orf40 C19orf40 TSACC TSACC ALKBH7 ALKBH7 SNCB SNCB
"TSACC" - TSSK6-activating co-chaperone protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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TSACCTSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family (125 aa)    
Predicted Functional Partners:
SNCB
Beta-synuclein; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease (134 aa)
      
        0.684
ALKBH7
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does [...] (221 aa)
      
        0.673
RIMBP3C
RIMS binding protein 3C; Belongs to the RIMBP family (1639 aa)
            
  0.647
ALS2CR11
C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (1820 aa)
            
  0.606
SLC25A51
Solute carrier family 25 member 51 (297 aa)
            
  0.600
RIMBP3B
RIMS binding protein 3B (1639 aa)
            
  0.595
ARMC12
Armadillo repeat containing 12 (367 aa)
      
   
  0.590
C19orf40
Fanconi anemia core complex-associated protein 24; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (215 aa)
      
        0.563
ANKRD7
Ankyrin repeat domain-containing protein 7; Ankyrin repeat domain containing (254 aa)
            
  0.562
FSCB
Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium (825 aa)
            
  0.560
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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