• Version:
  • 11.0 [archived version]
STRINGSTRING
FCGBP FCGBP TFF3 TFF3 RETNLB RETNLB LGALS14 LGALS14 ENDOG ENDOG ITLN2 ITLN2 FAM181B FAM181B ITLN1 ITLN1 SULT2B1 SULT2B1 PRG3 PRG3 IRGC IRGC
"ITLN2" - Intelectin-2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
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[Homology]
Score
ITLN2Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing (325 aa)    
Predicted Functional Partners:
ENDOG
Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity); Belongs to the DNA/RNA non-specific endonuclease family (297 aa)
       
      0.874
ITLN1
Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta- linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D- manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against micr [...] (313 aa)
     
 
0.864
SULT2B1
Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...] (365 aa)
           
  0.542
PRG3
Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils; C-type lectin domain containing (225 aa)
           
  0.536
LGALS14
Placental protein 13-like; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins (168 aa)
           
  0.530
FAM181B
Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family (426 aa)
           
  0.473
IRGC
Interferon-inducible GTPase 5; Immunity related GTPase cinema (463 aa)
           
  0.470
TFF3
Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (94 aa)
     
   
  0.449
RETNLB
Resistin-like beta; Probable hormone; Belongs to the resistin/FIZZ family (111 aa)
     
   
  0.441
FCGBP
Fc fragment of IgG binding protein (4204 aa)
           
  0.427
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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