node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENDOG | ITLN1 | ENSP00000361725 | ENSP00000323587 | Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity); Belongs to the DNA/RNA non-specific endonuclease family | Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta- linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D- manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against micr [...] | 0.798 |
ENDOG | ITLN2 | ENSP00000361725 | ENSP00000357008 | Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity); Belongs to the DNA/RNA non-specific endonuclease family | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | 0.874 |
FAM181B | ITLN2 | ENSP00000365295 | ENSP00000357008 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | 0.473 |
FCGBP | ITLN2 | ENSP00000481056 | ENSP00000357008 | Fc fragment of IgG binding protein | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | 0.427 |
FCGBP | RETNLB | ENSP00000481056 | ENSP00000295755 | Fc fragment of IgG binding protein | Resistin-like beta; Probable hormone; Belongs to the resistin/FIZZ family | 0.452 |
FCGBP | TFF3 | ENSP00000481056 | ENSP00000430690 | Fc fragment of IgG binding protein | Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) | 0.506 |
IRGC | ITLN2 | ENSP00000244314 | ENSP00000357008 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | 0.470 |
ITLN1 | ENDOG | ENSP00000323587 | ENSP00000361725 | Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta- linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D- manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against micr [...] | Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity); Belongs to the DNA/RNA non-specific endonuclease family | 0.798 |
ITLN1 | ITLN2 | ENSP00000323587 | ENSP00000357008 | Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta- linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D- manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against micr [...] | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | 0.864 |
ITLN1 | SULT2B1 | ENSP00000323587 | ENSP00000201586 | Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta- linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D- manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against micr [...] | Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...] | 0.542 |
ITLN2 | ENDOG | ENSP00000357008 | ENSP00000361725 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity); Belongs to the DNA/RNA non-specific endonuclease family | 0.874 |
ITLN2 | FAM181B | ENSP00000357008 | ENSP00000365295 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family | 0.473 |
ITLN2 | FCGBP | ENSP00000357008 | ENSP00000481056 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Fc fragment of IgG binding protein | 0.427 |
ITLN2 | IRGC | ENSP00000357008 | ENSP00000244314 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.470 |
ITLN2 | ITLN1 | ENSP00000357008 | ENSP00000323587 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta- linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D- manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against micr [...] | 0.864 |
ITLN2 | LGALS14 | ENSP00000357008 | ENSP00000353893 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Placental protein 13-like; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins | 0.530 |
ITLN2 | PRG3 | ENSP00000357008 | ENSP00000287143 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils; C-type lectin domain containing | 0.536 |
ITLN2 | RETNLB | ENSP00000357008 | ENSP00000295755 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Resistin-like beta; Probable hormone; Belongs to the resistin/FIZZ family | 0.441 |
ITLN2 | SULT2B1 | ENSP00000357008 | ENSP00000201586 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...] | 0.542 |
ITLN2 | TFF3 | ENSP00000357008 | ENSP00000430690 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) | 0.449 |