KLHDC9 protein (human) - STRING database

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KLHDC9

Kelch domain containing 9 (349 aa)

Predicted Functional Partners:

ARHGAP30

0.760

CCNA1

0.697

PROCA1

0.655

STK36

0.633

INCA1

0.589

SLAMF8

0.588

KLHDC8B

0.574

MAST2

0.568

THSD7B

0.479

BPTF

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP30	KLHDC9	ENSP00000356992	ENSP00000356990	Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42	Kelch domain containing 9	0.760
ARHGAP30	SLAMF8	ENSP00000356992	ENSP00000289707	Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42	SLAM family member 8; May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor; CD molecules	0.615
BPTF	KLHDC9	ENSP00000307208	ENSP00000356990	Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family	Kelch domain containing 9	0.473
CCNA1	INCA1	ENSP00000255465	ENSP00000458316	Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily	Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family	0.666
CCNA1	KLHDC9	ENSP00000255465	ENSP00000356990	Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily	Kelch domain containing 9	0.697
CCNA1	PROCA1	ENSP00000255465	ENSP00000301039	Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily	Protein interacting with cyclin A1; Belongs to the PROCA1 family	0.550
INCA1	CCNA1	ENSP00000458316	ENSP00000255465	Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family	Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily	0.666
INCA1	KLHDC9	ENSP00000458316	ENSP00000356990	Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family	Kelch domain containing 9	0.589
INCA1	PROCA1	ENSP00000458316	ENSP00000301039	Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family	Protein interacting with cyclin A1; Belongs to the PROCA1 family	0.549
KLHDC8B	KLHDC9	ENSP00000327468	ENSP00000356990	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells	Kelch domain containing 9	0.574
KLHDC9	ARHGAP30	ENSP00000356990	ENSP00000356992	Kelch domain containing 9	Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42	0.760
KLHDC9	BPTF	ENSP00000356990	ENSP00000307208	Kelch domain containing 9	Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family	0.473
KLHDC9	CCNA1	ENSP00000356990	ENSP00000255465	Kelch domain containing 9	Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily	0.697
KLHDC9	INCA1	ENSP00000356990	ENSP00000458316	Kelch domain containing 9	Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family	0.589
KLHDC9	KLHDC8B	ENSP00000356990	ENSP00000327468	Kelch domain containing 9	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells	0.574
KLHDC9	MAST2	ENSP00000356990	ENSP00000354671	Kelch domain containing 9	Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); PDZ domain containing	0.568
KLHDC9	PROCA1	ENSP00000356990	ENSP00000301039	Kelch domain containing 9	Protein interacting with cyclin A1; Belongs to the PROCA1 family	0.655
KLHDC9	SLAMF8	ENSP00000356990	ENSP00000289707	Kelch domain containing 9	SLAM family member 8; May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor; CD molecules	0.588
KLHDC9	STK36	ENSP00000356990	ENSP00000295709	Kelch domain containing 9	Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...]	0.633
KLHDC9	THSD7B	ENSP00000356990	ENSP00000272643	Kelch domain containing 9	Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B	0.479

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