| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCY3 | KLHL29 | ENSP00000260600 | ENSP00000420659 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases | Kelch-like protein 29; Kelch like family member 29; BTB domain containing | 0.673 |
| ADCY3 | MOXD1 | ENSP00000260600 | ENSP00000356940 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | 0.636 |
| ADCY3 | SNX9 | ENSP00000260600 | ENSP00000376024 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promot [...] | 0.487 |
| ADCY3 | TAAR5 | ENSP00000260600 | ENSP00000258034 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases | Trace amine-associated receptor 5; Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase | 0.914 |
| ADCY3 | TAAR6 | ENSP00000260600 | ENSP00000275198 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases | Trace amine-associated receptor 6; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood | 0.911 |
| HCCS | MOXD1 | ENSP00000326579 | ENSP00000356940 | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | 0.746 |
| KIAA0100 | MOXD1 | ENSP00000436773 | ENSP00000356940 | Protein KIAA0100; May be involved in membrane trafficking; Belongs to the SABRE family | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | 0.634 |
| KLHL29 | ADCY3 | ENSP00000420659 | ENSP00000260600 | Kelch-like protein 29; Kelch like family member 29; BTB domain containing | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases | 0.673 |
| KLHL29 | MOXD1 | ENSP00000420659 | ENSP00000356940 | Kelch-like protein 29; Kelch like family member 29; BTB domain containing | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | 0.690 |
| KLHL29 | SNX9 | ENSP00000420659 | ENSP00000376024 | Kelch-like protein 29; Kelch like family member 29; BTB domain containing | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promot [...] | 0.677 |
| MOXD1 | ADCY3 | ENSP00000356940 | ENSP00000260600 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases | 0.636 |
| MOXD1 | HCCS | ENSP00000356940 | ENSP00000326579 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c | 0.746 |
| MOXD1 | KIAA0100 | ENSP00000356940 | ENSP00000436773 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Protein KIAA0100; May be involved in membrane trafficking; Belongs to the SABRE family | 0.634 |
| MOXD1 | KLHL29 | ENSP00000356940 | ENSP00000420659 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Kelch-like protein 29; Kelch like family member 29; BTB domain containing | 0.690 |
| MOXD1 | SEMA5A | ENSP00000356940 | ENSP00000371936 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis [...] | 0.643 |
| MOXD1 | SNX9 | ENSP00000356940 | ENSP00000376024 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promot [...] | 0.631 |
| MOXD1 | STX7 | ENSP00000356940 | ENSP00000356918 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes; Belongs to the syntaxin family | 0.811 |
| MOXD1 | TAAR5 | ENSP00000356940 | ENSP00000258034 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Trace amine-associated receptor 5; Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase | 0.835 |
| MOXD1 | TAAR6 | ENSP00000356940 | ENSP00000275198 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Trace amine-associated receptor 6; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood | 0.712 |
| MOXD1 | TMEM163 | ENSP00000356940 | ENSP00000281924 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family | Transmembrane protein 163; May bind zinc and other divalent cations and recruit them to vesicular organelles | 0.724 |
