| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD26 | C1orf111 | ENSP00000365255 | ENSP00000356912 | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior; Ankyrin repeat domain containing | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | 0.515 |
| ANKRD26 | PCDHA2 | ENSP00000365255 | ENSP00000431748 | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior; Ankyrin repeat domain containing | Protocadherin alpha-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.406 |
| ANKRD26 | PRSS54 | ENSP00000365255 | ENSP00000219301 | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior; Ankyrin repeat domain containing | Serine protease 54 | 0.404 |
| C1orf111 | ANKRD26 | ENSP00000356912 | ENSP00000365255 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior; Ankyrin repeat domain containing | 0.515 |
| C1orf111 | CSNK1A1 | ENSP00000356912 | ENSP00000421689 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | 0.821 |
| C1orf111 | DNAH3 | ENSP00000356912 | ENSP00000261383 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family | 0.542 |
| C1orf111 | GAPVD1 | ENSP00000356912 | ENSP00000377664 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.823 |
| C1orf111 | HEPHL1 | ENSP00000356912 | ENSP00000313699 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | 0.630 |
| C1orf111 | MDM4 | ENSP00000356912 | ENSP00000356150 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions; Ring finger proteins | 0.798 |
| C1orf111 | PCDHA2 | ENSP00000356912 | ENSP00000431748 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Protocadherin alpha-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.670 |
| C1orf111 | PRSS54 | ENSP00000356912 | ENSP00000219301 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Serine protease 54 | 0.670 |
| C1orf111 | SNX24 | ENSP00000356912 | ENSP00000261369 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.686 |
| C1orf111 | ZNF208 | ENSP00000356912 | ENSP00000380315 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Zinc finger protein 208; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.557 |
| CSNK1A1 | C1orf111 | ENSP00000421689 | ENSP00000356912 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | 0.821 |
| CSNK1A1 | GAPVD1 | ENSP00000421689 | ENSP00000377664 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.804 |
| CSNK1A1 | MDM4 | ENSP00000421689 | ENSP00000356150 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions; Ring finger proteins | 0.488 |
| CSNK1A1 | SNX24 | ENSP00000421689 | ENSP00000261369 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.512 |
| DNAH3 | C1orf111 | ENSP00000261383 | ENSP00000356912 | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | 0.542 |
| DNAH3 | PCDHA2 | ENSP00000261383 | ENSP00000431748 | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family | Protocadherin alpha-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.440 |
| DNAH3 | PRSS54 | ENSP00000261383 | ENSP00000219301 | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family | Serine protease 54 | 0.422 |
