node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DBX1 | OLIG3 | ENSP00000436881 | ENSP00000356708 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); NKL subclass homeoboxes and pseudogenes | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | 0.566 |
IL20RA | OLIG3 | ENSP00000314976 | ENSP00000356708 | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26; Interleukin receptors | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | 0.562 |
IL20RA | SLC35D3 | ENSP00000314976 | ENSP00000333591 | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26; Interleukin receptors | Solute carrier family 35 member D3; May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules; Solute carriers | 0.592 |
MAST3 | NAIF1 | ENSP00000262811 | ENSP00000362170 | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family | 0.649 |
MAST3 | OLIG3 | ENSP00000262811 | ENSP00000356708 | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | 0.578 |
MAST3 | TNFAIP3 | ENSP00000262811 | ENSP00000481570 | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] | 0.477 |
NAIF1 | MAST3 | ENSP00000362170 | ENSP00000262811 | Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | 0.649 |
NAIF1 | OLIG3 | ENSP00000362170 | ENSP00000356708 | Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | 0.601 |
NKX2-2 | OLIG3 | ENSP00000366347 | ENSP00000356708 | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | 0.677 |
OLIG3 | DBX1 | ENSP00000356708 | ENSP00000436881 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); NKL subclass homeoboxes and pseudogenes | 0.566 |
OLIG3 | IL20RA | ENSP00000356708 | ENSP00000314976 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26; Interleukin receptors | 0.562 |
OLIG3 | MAST3 | ENSP00000356708 | ENSP00000262811 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | 0.578 |
OLIG3 | NAIF1 | ENSP00000356708 | ENSP00000362170 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family | 0.601 |
OLIG3 | NKX2-2 | ENSP00000356708 | ENSP00000366347 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family | 0.677 |
OLIG3 | SLC35D3 | ENSP00000356708 | ENSP00000333591 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Solute carrier family 35 member D3; May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules; Solute carriers | 0.609 |
OLIG3 | TCF12 | ENSP00000356708 | ENSP00000388940 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.766 |
OLIG3 | TCF3 | ENSP00000356708 | ENSP00000262965 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.645 |
OLIG3 | TNFAIP3 | ENSP00000356708 | ENSP00000481570 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] | 0.650 |
OLIG3 | TRAF1 | ENSP00000356708 | ENSP00000362994 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2; TNF receptor associated factors | 0.584 |
SLC35D3 | IL20RA | ENSP00000333591 | ENSP00000314976 | Solute carrier family 35 member D3; May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules; Solute carriers | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26; Interleukin receptors | 0.592 |