node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CENPL | ZBTB37 | ENSP00000348527 | ENSP00000356674 | Centromere protein L; Constitutive centromere associated network | Zinc finger and BTB domain-containing protein 37; May be involved in transcriptional regulation; BTB domain containing | 0.665 |
DARS2 | OSBPL9 | ENSP00000355086 | ENSP00000412733 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family | 0.692 |
DARS2 | RHOD | ENSP00000355086 | ENSP00000308576 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family | 0.514 |
DARS2 | RHOF | ENSP00000355086 | ENSP00000267205 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin- based morphology; Rho family GTPases | 0.641 |
DARS2 | SETD1A | ENSP00000355086 | ENSP00000262519 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Lysine methyltransferases | 0.438 |
DARS2 | SETD1B | ENSP00000355086 | ENSP00000442924 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro; Belongs t [...] | 0.656 |
DARS2 | TOR3A | ENSP00000355086 | ENSP00000356599 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | Torsin-3A; Minor histocompatibility antigens | 0.673 |
DARS2 | ZBTB37 | ENSP00000355086 | ENSP00000356674 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | Zinc finger and BTB domain-containing protein 37; May be involved in transcriptional regulation; BTB domain containing | 0.777 |
OSBPL9 | DARS2 | ENSP00000412733 | ENSP00000355086 | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | 0.692 |
OSBPL9 | RHOF | ENSP00000412733 | ENSP00000267205 | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family | Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin- based morphology; Rho family GTPases | 0.654 |
OSBPL9 | SETD1A | ENSP00000412733 | ENSP00000262519 | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Lysine methyltransferases | 0.442 |
OSBPL9 | SETD1B | ENSP00000412733 | ENSP00000442924 | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro; Belongs t [...] | 0.659 |
OSBPL9 | TOR3A | ENSP00000412733 | ENSP00000356599 | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family | Torsin-3A; Minor histocompatibility antigens | 0.675 |
OSBPL9 | ZBTB37 | ENSP00000412733 | ENSP00000356674 | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family | Zinc finger and BTB domain-containing protein 37; May be involved in transcriptional regulation; BTB domain containing | 0.788 |
RC3H1 | ZBTB37 | ENSP00000356669 | ENSP00000356674 | Roquin-1; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3’-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3’-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helpe [...] | Zinc finger and BTB domain-containing protein 37; May be involved in transcriptional regulation; BTB domain containing | 0.522 |
RHOD | DARS2 | ENSP00000308576 | ENSP00000355086 | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | 0.514 |
RHOD | RHOF | ENSP00000308576 | ENSP00000267205 | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family | Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin- based morphology; Rho family GTPases | 0.904 |
RHOD | TOR3A | ENSP00000308576 | ENSP00000356599 | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family | Torsin-3A; Minor histocompatibility antigens | 0.513 |
RHOD | ZBTB37 | ENSP00000308576 | ENSP00000356674 | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family | Zinc finger and BTB domain-containing protein 37; May be involved in transcriptional regulation; BTB domain containing | 0.525 |
RHOF | DARS2 | ENSP00000267205 | ENSP00000355086 | Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin- based morphology; Rho family GTPases | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily | 0.641 |