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STRINGSTRING
FBXO10 FBXO10 FHL5 FHL5 SATL1 SATL1 SHCBP1L SHCBP1L C8orf74 C8orf74 HSPA2 HSPA2 ACTL9 ACTL9 C1orf141 C1orf141 DNAJC5G DNAJC5G CCDC116 CCDC116 RBM44 RBM44
"SHCBP1L" - Testicular spindle-associated protein SHCBP1L in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SHCBP1LTesticular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells (653 aa)    
Predicted Functional Partners:
HSPA2
Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...] (639 aa)
            
  0.770
FHL5
Four and a half LIM domains protein 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner; LIM domain containing (284 aa)
            
  0.700
CCDC116
Coiled-coil domain containing 116 (613 aa)
            
  0.689
C1orf141
Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141 (400 aa)
            
  0.688
ACTL9
Actin-like protein 9; Actin related proteins (416 aa)
            
  0.681
RBM44
RNA-binding protein 44; Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity); RNA binding motif containing (1052 aa)
            
  0.673
FBXO10
F-box only protein 10; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2; F-boxes other (956 aa)
            
  0.660
C8orf74
Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74 (294 aa)
      
   
  0.657
SATL1
Spermidine/spermine N1-acetyl transferase like 1; GCN5 related N-acetyltransferases (632 aa)
            
  0.557
DNAJC5G
DnaJ heat shock protein family member C5 gamma (189 aa)
      
   
  0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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