RAET1G protein (human) - STRING database

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RAET1G

UL-16 binding protein 5; Isoform 1- Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity (334 aa)

Predicted Functional Partners:

ENSG00000255819

0.935

ULBP2

0.917

RAET1L

0.906

PSCA

0.904

SPACA4

0.904

LY6K

0.903

MSLN

0.903

LY6D

0.903

LYPD3

0.902

CD109

0.901

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD109	LY6D	ENSP00000287097	ENSP00000301263	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	0.900
CD109	LY6K	ENSP00000287097	ENSP00000292430	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth; LY6/PLAUR domain containing	0.903
CD109	LYPD3	ENSP00000287097	ENSP00000244333	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression; LY6/PLAUR domain containing	0.900
CD109	MSLN	ENSP00000287097	ENSP00000372313	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	Mesothelin; Membrane-anchored forms may play a role in cellular adhesion	0.925
CD109	PSCA	ENSP00000287097	ENSP00000301258	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	Prostate stem cell antigen; May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro; LY6/PLAUR domain containing	0.900
CD109	RAET1G	ENSP00000287097	ENSP00000356329	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	UL-16 binding protein 5; Isoform 1- Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity	0.901
CD109	RAET1L	ENSP00000287097	ENSP00000356310	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	UL16-binding protein 6; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity	0.900
CD109	SPACA4	ENSP00000287097	ENSP00000312774	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing	0.904
CD109	ULBP2	ENSP00000287097	ENSP00000356320	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	UL16-binding protein 2; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family	0.903
ENSG00000255819	RAET1G	ENSP00000480609	ENSP00000356329	NKG2-D type II integral membrane protein; Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expre [...]	UL-16 binding protein 5; Isoform 1- Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity	0.935
ENSG00000255819	RAET1L	ENSP00000480609	ENSP00000356310	NKG2-D type II integral membrane protein; Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expre [...]	UL16-binding protein 6; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity	0.986
ENSG00000255819	ULBP2	ENSP00000480609	ENSP00000356320	NKG2-D type II integral membrane protein; Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expre [...]	UL16-binding protein 2; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family	0.982
LY6D	CD109	ENSP00000301263	ENSP00000287097	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family	0.900
LY6D	LY6K	ENSP00000301263	ENSP00000292430	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth; LY6/PLAUR domain containing	0.944
LY6D	LYPD3	ENSP00000301263	ENSP00000244333	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression; LY6/PLAUR domain containing	0.931
LY6D	MSLN	ENSP00000301263	ENSP00000372313	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	Mesothelin; Membrane-anchored forms may play a role in cellular adhesion	0.903
LY6D	PSCA	ENSP00000301263	ENSP00000301258	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	Prostate stem cell antigen; May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro; LY6/PLAUR domain containing	0.925
LY6D	RAET1G	ENSP00000301263	ENSP00000356329	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	UL-16 binding protein 5; Isoform 1- Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity	0.903
LY6D	RAET1L	ENSP00000301263	ENSP00000356310	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	UL16-binding protein 6; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity	0.910
LY6D	SPACA4	ENSP00000301263	ENSP00000312774	Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PLAUR domain containing	Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing	0.931

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