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STRINGSTRING
FBXO39 FBXO39 TRIP12 TRIP12 C1orf177 C1orf177 SENP8 SENP8 LEMD1 LEMD1 LEMD2 LEMD2 LEMD3 LEMD3 BANF1 BANF1 PMM2 PMM2 CCDC33 CCDC33 CCDC110 CCDC110
"LEMD1" - LEM domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LEMD1LEM domain containing 1 (181 aa)    
Predicted Functional Partners:
C1orf177
Lymphocyte expansion molecule; Chromosome 1 open reading frame 177 (418 aa)
            
  0.900
BANF1
Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging; Belongs to the BAF family (89 aa)
      
   
  0.705
LEMD3
Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest; LEM domain containing (911 aa)
        
 
  0.655
PMM2
Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions; HAD Asp-based non-protein phosphatases (246 aa)
            
  0.644
TRIP12
E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...] (2040 aa)
            
  0.626
FBXO39
F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other (442 aa)
            
  0.612
SENP8
Sentrin-specific protease 8; Protease that catalyzes two essential functions in the NEDD8 pathway- processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53; SUMO specific peptidases (212 aa)
            
  0.584
CCDC110
Coiled-coil domain containing 110 (833 aa)
            
  0.547
LEMD2
LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope; LEM domain containing (503 aa)
            
  0.487
CCDC33
Coiled-coil domain containing 33 (755 aa)
      
   
  0.485
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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