MFSD4 protein (human) - STRING database

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MFSD4

Major facilitator superfamily domain containing 4 (514 aa)

Predicted Functional Partners:

MFSD9

0.702

SCNN1A

0.693

CBY1

0.692

MFSD10

0.686

TMEM180

0.672

INHBA

0.657

MFSD11

0.646

MFSD5

0.619

MFSD6L

0.619

MFSD8

0.612

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBY1	INHBA	ENSP00000478962	ENSP00000242208	Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation; Belongs to the chibby family	Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family	0.633
CBY1	MFSD4	ENSP00000478962	ENSP00000356115	Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation; Belongs to the chibby family	Major facilitator superfamily domain containing 4	0.692
CBY1	SCNN1A	ENSP00000478962	ENSP00000353292	Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation; Belongs to the chibby family	Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception	0.643
INHBA	CBY1	ENSP00000242208	ENSP00000478962	Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family	Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation; Belongs to the chibby family	0.633
INHBA	MFSD4	ENSP00000242208	ENSP00000356115	Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family	Major facilitator superfamily domain containing 4	0.657
INHBA	SCNN1A	ENSP00000242208	ENSP00000353292	Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family	Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception	0.643
MFSD10	MFSD11	ENSP00000332646	ENSP00000464932	Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	0.770
MFSD10	MFSD4	ENSP00000332646	ENSP00000356115	Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump	Major facilitator superfamily domain containing 4	0.686
MFSD10	MFSD5	ENSP00000332646	ENSP00000442688	Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump	Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily	0.801
MFSD10	MFSD6L	ENSP00000332646	ENSP00000330051	Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump	Major facilitator superfamily domain containing 6 like	0.562
MFSD10	MFSD8	ENSP00000332646	ENSP00000296468	Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily	0.737
MFSD10	TMEM180	ENSP00000332646	ENSP00000238936	Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump	Transmembrane protein 180	0.583
MFSD11	MFSD10	ENSP00000464932	ENSP00000332646	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump	0.770
MFSD11	MFSD4	ENSP00000464932	ENSP00000356115	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	Major facilitator superfamily domain containing 4	0.646
MFSD11	MFSD5	ENSP00000464932	ENSP00000442688	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily	0.873
MFSD11	MFSD6L	ENSP00000464932	ENSP00000330051	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	Major facilitator superfamily domain containing 6 like	0.666
MFSD11	MFSD8	ENSP00000464932	ENSP00000296468	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily	0.755
MFSD11	MFSD9	ENSP00000464932	ENSP00000258436	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	Major facilitator superfamily domain containing 9	0.685
MFSD11	TMEM180	ENSP00000464932	ENSP00000238936	UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family	Transmembrane protein 180	0.671
MFSD4	CBY1	ENSP00000356115	ENSP00000478962	Major facilitator superfamily domain containing 4	Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation; Belongs to the chibby family	0.692

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