ACAT2 protein (human) - STRING database

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ACAT2

Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 (397 aa)

Predicted Functional Partners:

HADH

0.991

HMGCS1

0.989

HMGCS2

0.980

HADHA

0.973

EHHADH

0.971

OXCT1

0.961

ACADS

0.958

HMGCL

0.954

HMGCLL1

0.951

OXCT2

0.950

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADS	ACAT2	ENSP00000242592	ENSP00000356015	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.958
ACADS	EHHADH	ENSP00000242592	ENSP00000231887	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family	0.960
ACADS	HADH	ENSP00000242592	ENSP00000474560	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family	0.927
ACADS	HADHA	ENSP00000242592	ENSP00000370023	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.972
ACADS	HMGCL	ENSP00000242592	ENSP00000363614	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism	0.418
ACAT2	ACADS	ENSP00000356015	ENSP00000242592	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	0.958
ACAT2	EHHADH	ENSP00000356015	ENSP00000231887	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family	0.971
ACAT2	HADH	ENSP00000356015	ENSP00000474560	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family	0.991
ACAT2	HADHA	ENSP00000356015	ENSP00000370023	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.973
ACAT2	HMGCL	ENSP00000356015	ENSP00000363614	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism	0.954
ACAT2	HMGCLL1	ENSP00000356015	ENSP00000381654	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues	0.951
ACAT2	HMGCS1	ENSP00000356015	ENSP00000322706	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.989
ACAT2	HMGCS2	ENSP00000356015	ENSP00000358414	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.980
ACAT2	OXCT1	ENSP00000356015	ENSP00000196371	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Succinyl-CoA-3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate; Belongs to the 3-oxoacid CoA-transferase family	0.961
ACAT2	OXCT2	ENSP00000356015	ENSP00000361914	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Succinyl-CoA-3-ketoacid coenzyme A transferase 2, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity); Belongs to the 3-oxoacid CoA-transferase family	0.950
EHHADH	ACADS	ENSP00000231887	ENSP00000242592	Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	0.960
EHHADH	ACAT2	ENSP00000231887	ENSP00000356015	Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.971
EHHADH	HADH	ENSP00000231887	ENSP00000474560	Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family	0.933
EHHADH	HADHA	ENSP00000231887	ENSP00000370023	Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.922
EHHADH	HMGCL	ENSP00000231887	ENSP00000363614	Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family	Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism	0.943

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