GPATCH2 protein (human) - STRING database

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GPATCH2

G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing (528 aa)

Predicted Functional Partners:

TFIP11

0.861

DHX15

0.822

NOB1

0.731

IGSF11

0.700

CEP55

0.693

LTV1

0.687

PINX1

0.668

PRSS50

0.630

SPATA17

0.629

BYSL

0.625

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BYSL	DHX15	ENSP00000230340	ENSP00000336741	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	0.955
BYSL	GPATCH2	ENSP00000230340	ENSP00000355902	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	0.625
BYSL	LTV1	ENSP00000230340	ENSP00000356548	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	0.999
BYSL	NOB1	ENSP00000230340	ENSP00000268802	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	RNA-binding protein NOB1; May play a role in mRNA degradation; Belongs to the NOB1 family	0.999
BYSL	PINX1	ENSP00000230340	ENSP00000318966	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor; Belongs to the PINX1 family	0.950
CEP55	GPATCH2	ENSP00000360540	ENSP00000355902	Centrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	0.693
CEP55	IGSF11	ENSP00000360540	ENSP00000377370	Centrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney	Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing	0.472
DHX15	BYSL	ENSP00000336741	ENSP00000230340	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	0.955
DHX15	GPATCH2	ENSP00000336741	ENSP00000355902	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	0.822
DHX15	LTV1	ENSP00000336741	ENSP00000356548	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	0.848
DHX15	NOB1	ENSP00000336741	ENSP00000268802	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	RNA-binding protein NOB1; May play a role in mRNA degradation; Belongs to the NOB1 family	0.878
DHX15	PINX1	ENSP00000336741	ENSP00000318966	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor; Belongs to the PINX1 family	0.972
DHX15	TFIP11	ENSP00000336741	ENSP00000384421	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrace [...]	0.999
GPATCH2	BYSL	ENSP00000355902	ENSP00000230340	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	0.625
GPATCH2	CEP55	ENSP00000355902	ENSP00000360540	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	Centrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney	0.693
GPATCH2	DHX15	ENSP00000355902	ENSP00000336741	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily	0.822
GPATCH2	IGSF11	ENSP00000355902	ENSP00000377370	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing	0.700
GPATCH2	LTV1	ENSP00000355902	ENSP00000356548	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	0.687
GPATCH2	NOB1	ENSP00000355902	ENSP00000268802	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	RNA-binding protein NOB1; May play a role in mRNA degradation; Belongs to the NOB1 family	0.731
GPATCH2	PINX1	ENSP00000355902	ENSP00000318966	G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing	PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor; Belongs to the PINX1 family	0.668

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