| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNBP | SPATA17 | ENSP00000410769 | ENSP00000355900 | Cellular nucleic acid-binding protein; Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression; Ring finger proteins | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.672 |
| FAM228A | SPATA17 | ENSP00000295150 | ENSP00000355900 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.585 |
| FEM1B | SPATA17 | ENSP00000307298 | ENSP00000355900 | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.626 |
| GPATCH2 | KCTD3 | ENSP00000355902 | ENSP00000259154 | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family | 0.607 |
| GPATCH2 | SPATA17 | ENSP00000355902 | ENSP00000355900 | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.629 |
| GSK3B | KCTD3 | ENSP00000324806 | ENSP00000259154 | Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family | 0.614 |
| GSK3B | SPATA17 | ENSP00000324806 | ENSP00000355900 | Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.547 |
| KCTD3 | GPATCH2 | ENSP00000259154 | ENSP00000355902 | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing | 0.607 |
| KCTD3 | GSK3B | ENSP00000259154 | ENSP00000324806 | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family | Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | 0.614 |
| KCTD3 | SPATA17 | ENSP00000259154 | ENSP00000355900 | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.718 |
| RNFT1 | SEPT12 | ENSP00000304670 | ENSP00000268231 | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis; Ring finger proteins | Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPT7, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family | 0.581 |
| RNFT1 | SPATA17 | ENSP00000304670 | ENSP00000355900 | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis; Ring finger proteins | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.570 |
| SEPT12 | RNFT1 | ENSP00000268231 | ENSP00000304670 | Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPT7, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis; Ring finger proteins | 0.581 |
| SEPT12 | SPATA17 | ENSP00000268231 | ENSP00000355900 | Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPT7, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.597 |
| SEPT12 | TSSK6 | ENSP00000268231 | ENSP00000466477 | Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPT7, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity) | 0.515 |
| SPATA17 | CNBP | ENSP00000355900 | ENSP00000410769 | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | Cellular nucleic acid-binding protein; Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression; Ring finger proteins | 0.672 |
| SPATA17 | FAM228A | ENSP00000355900 | ENSP00000295150 | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | 0.585 |
| SPATA17 | FEM1B | ENSP00000355900 | ENSP00000307298 | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family | 0.626 |
| SPATA17 | GPATCH2 | ENSP00000355900 | ENSP00000355902 | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing | 0.629 |
| SPATA17 | GSK3B | ENSP00000355900 | ENSP00000324806 | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | 0.547 |
