FAM89A protein (human) - STRING database

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FAM89A

Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family (184 aa)

Predicted Functional Partners:

UBXN2B

0.622

GEMIN2

0.557

GFRA3

0.553

PURB

0.550

PTGIR

0.494

ZFHX2

0.474

FAM78A

0.474

PSPH

0.473

CLTA

0.469

RNF145

0.455

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLTA	FAM89A	ENSP00000242285	ENSP00000355614	Clathrin light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.469
FAM78A	FAM89A	ENSP00000361345	ENSP00000355614	Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.474
FAM89A	CLTA	ENSP00000355614	ENSP00000242285	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Clathrin light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge	0.469
FAM89A	FAM78A	ENSP00000355614	ENSP00000361345	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family	0.474
FAM89A	GEMIN2	ENSP00000355614	ENSP00000308533	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...]	0.557
FAM89A	GFRA3	ENSP00000355614	ENSP00000274721	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	GDNF family receptor alpha-3; Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase; Belongs to the GDNFR family	0.553
FAM89A	PSPH	ENSP00000355614	ENSP00000378854	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates; HAD Asp-based non-protein phosphatases	0.473
FAM89A	PTGIR	ENSP00000355614	ENSP00000291294	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase	0.494
FAM89A	PURB	ENSP00000355614	ENSP00000379051	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. Ma [...]	0.550
FAM89A	RNF145	ENSP00000355614	ENSP00000430955	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Ring finger protein 145	0.455
FAM89A	UBXN2B	ENSP00000355614	ENSP00000382507	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	UBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity; Belongs to the NSFL1C family	0.622
FAM89A	ZFHX2	ENSP00000355614	ENSP00000413418	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	0.474
GEMIN2	FAM89A	ENSP00000308533	ENSP00000355614	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...]	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.557
GFRA3	FAM89A	ENSP00000274721	ENSP00000355614	GDNF family receptor alpha-3; Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase; Belongs to the GDNFR family	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.553
GFRA3	PTGIR	ENSP00000274721	ENSP00000291294	GDNF family receptor alpha-3; Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase; Belongs to the GDNFR family	Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase	0.401
PSPH	FAM89A	ENSP00000378854	ENSP00000355614	Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates; HAD Asp-based non-protein phosphatases	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.473
PTGIR	FAM89A	ENSP00000291294	ENSP00000355614	Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.494
PTGIR	GFRA3	ENSP00000291294	ENSP00000274721	Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase	GDNF family receptor alpha-3; Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase; Belongs to the GDNFR family	0.401
PURB	FAM89A	ENSP00000379051	ENSP00000355614	Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. Ma [...]	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.550
RNF145	FAM89A	ENSP00000430955	ENSP00000355614	Ring finger protein 145	Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family	0.455

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