| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF10 | EFHD2 | ENSP00000340297 | ENSP00000365147 | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors | EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance; EF-hand domain containing | 0.511 |
| ARHGEF10 | SDK2 | ENSP00000340297 | ENSP00000376421 | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | 0.426 |
| ARHGEF10 | TRIM67 | ENSP00000340297 | ENSP00000355613 | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.632 |
| BBOX1 | TRIM17 | ENSP00000263182 | ENSP00000355658 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase; Belongs to the TRIM/RBCC family | 0.861 |
| BBOX1 | TRIM67 | ENSP00000263182 | ENSP00000355613 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.646 |
| DCC | TRIM67 | ENSP00000389140 | ENSP00000355613 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.738 |
| EFHD2 | ARHGEF10 | ENSP00000365147 | ENSP00000340297 | EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance; EF-hand domain containing | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors | 0.511 |
| EFHD2 | SDK2 | ENSP00000365147 | ENSP00000376421 | EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance; EF-hand domain containing | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | 0.407 |
| EFHD2 | TRIM67 | ENSP00000365147 | ENSP00000355613 | EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance; EF-hand domain containing | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.602 |
| IGDCC3 | SDK2 | ENSP00000332773 | ENSP00000376421 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | 0.446 |
| IGDCC3 | TRIM67 | ENSP00000332773 | ENSP00000355613 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.677 |
| NEO1 | TRIM67 | ENSP00000341198 | ENSP00000355613 | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.725 |
| NLRP6 | TRIM67 | ENSP00000309767 | ENSP00000355613 | NACHT, LRR and PYD domains-containing protein 6; As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1- catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity). Essen [...] | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.571 |
| SDK2 | ARHGEF10 | ENSP00000376421 | ENSP00000340297 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors | 0.426 |
| SDK2 | EFHD2 | ENSP00000376421 | ENSP00000365147 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance; EF-hand domain containing | 0.407 |
| SDK2 | IGDCC3 | ENSP00000376421 | ENSP00000332773 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | 0.446 |
| SDK2 | TRIM67 | ENSP00000376421 | ENSP00000355613 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.672 |
| TRIM17 | BBOX1 | ENSP00000355658 | ENSP00000263182 | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase; Belongs to the TRIM/RBCC family | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | 0.861 |
| TRIM17 | TRIM67 | ENSP00000355658 | ENSP00000355613 | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase; Belongs to the TRIM/RBCC family | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | 0.727 |
| TRIM67 | ARHGEF10 | ENSP00000355613 | ENSP00000340297 | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors | 0.632 |
