C1orf131 protein (human) - STRING database

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C1orf131

Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131 (293 aa)

Predicted Functional Partners:

CCDC137

0.734

DDX18

0.591

DDX27

0.589

KIAA0020

0.570

CIRH1A

0.559

UTP3

0.548

RRP1

0.420

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf131	CCDC137	ENSP00000355609	ENSP00000329360	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	Coiled-coil domain containing 137	0.734
C1orf131	CIRH1A	ENSP00000355609	ENSP00000327179	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	0.559
C1orf131	DDX18	ENSP00000355609	ENSP00000263239	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	0.591
C1orf131	DDX27	ENSP00000355609	ENSP00000483495	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases	0.589
C1orf131	KIAA0020	ENSP00000355609	ENSP00000380982	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.570
C1orf131	RRP1	ENSP00000355609	ENSP00000417464	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	Ribosomal RNA processing protein 1 homolog A; Plays a critical role in the generation of 28S rRNA; Belongs to the RRP1 family	0.420
C1orf131	UTP3	ENSP00000355609	ENSP00000254803	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	Something about silencing protein 10; Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity); Belongs to the SAS10 family	0.548
CCDC137	C1orf131	ENSP00000329360	ENSP00000355609	Coiled-coil domain containing 137	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	0.734
CCDC137	CIRH1A	ENSP00000329360	ENSP00000327179	Coiled-coil domain containing 137	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	0.444
CCDC137	DDX18	ENSP00000329360	ENSP00000263239	Coiled-coil domain containing 137	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	0.440
CCDC137	DDX27	ENSP00000329360	ENSP00000483495	Coiled-coil domain containing 137	Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases	0.491
CCDC137	KIAA0020	ENSP00000329360	ENSP00000380982	Coiled-coil domain containing 137	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.450
CIRH1A	C1orf131	ENSP00000327179	ENSP00000355609	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	0.559
CIRH1A	CCDC137	ENSP00000327179	ENSP00000329360	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	Coiled-coil domain containing 137	0.444
CIRH1A	DDX18	ENSP00000327179	ENSP00000263239	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	0.942
CIRH1A	DDX27	ENSP00000327179	ENSP00000483495	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases	0.918
CIRH1A	KIAA0020	ENSP00000327179	ENSP00000380982	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.916
CIRH1A	RRP1	ENSP00000327179	ENSP00000417464	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	Ribosomal RNA processing protein 1 homolog A; Plays a critical role in the generation of 28S rRNA; Belongs to the RRP1 family	0.965
CIRH1A	UTP3	ENSP00000327179	ENSP00000254803	U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A’, A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV	Something about silencing protein 10; Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity); Belongs to the SAS10 family	0.998
DDX18	C1orf131	ENSP00000263239	ENSP00000355609	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131	0.591

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