| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GPR107 | GPR137B | ENSP00000361483 | ENSP00000355551 | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | 0.619 |
| GPR107 | GPR143 | ENSP00000361483 | ENSP00000417161 | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport; 7TM orphan receptors | 0.471 |
| GPR107 | GPR157 | ENSP00000361483 | ENSP00000366628 | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger; 7TM orphan receptors | 0.564 |
| GPR108 | GPR137B | ENSP00000264080 | ENSP00000355551 | G protein-coupled receptor 108; 7TM orphan receptors | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | 0.594 |
| GPR108 | GPR143 | ENSP00000264080 | ENSP00000417161 | G protein-coupled receptor 108; 7TM orphan receptors | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport; 7TM orphan receptors | 0.485 |
| GPR108 | GPR157 | ENSP00000264080 | ENSP00000366628 | G protein-coupled receptor 108; 7TM orphan receptors | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger; 7TM orphan receptors | 0.586 |
| GPR114 | GPR137B | ENSP00000342981 | ENSP00000355551 | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide- binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking) | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | 0.558 |
| GPR114 | GPR174 | ENSP00000342981 | ENSP00000276077 | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide- binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking) | Probable G-protein coupled receptor 174; Putative receptor for purines coupled to G-proteins; G protein-coupled receptors, Class A orphans | 0.738 |
| GPR137B | GPR107 | ENSP00000355551 | ENSP00000361483 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | 0.619 |
| GPR137B | GPR108 | ENSP00000355551 | ENSP00000264080 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | G protein-coupled receptor 108; 7TM orphan receptors | 0.594 |
| GPR137B | GPR114 | ENSP00000355551 | ENSP00000342981 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide- binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking) | 0.558 |
| GPR137B | GPR143 | ENSP00000355551 | ENSP00000417161 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport; 7TM orphan receptors | 0.497 |
| GPR137B | GPR155 | ENSP00000355551 | ENSP00000376335 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | Integral membrane protein GPR155; G protein-coupled receptor 155 | 0.503 |
| GPR137B | GPR157 | ENSP00000355551 | ENSP00000366628 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger; 7TM orphan receptors | 0.503 |
| GPR137B | GPR174 | ENSP00000355551 | ENSP00000276077 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | Probable G-protein coupled receptor 174; Putative receptor for purines coupled to G-proteins; G protein-coupled receptors, Class A orphans | 0.598 |
| GPR137B | GPRC5C | ENSP00000355551 | ENSP00000376403 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways; G protein-coupled receptors, Class C orphans | 0.561 |
| GPR137B | TM7SF3 | ENSP00000355551 | ENSP00000342322 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells. Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) | 0.568 |
| GPR137B | ZNFX1 | ENSP00000355551 | ENSP00000379412 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family | Zinc finger NFX1-type containing 1; UPF1 like RNA helicases | 0.491 |
| GPR143 | GPR107 | ENSP00000417161 | ENSP00000361483 | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport; 7TM orphan receptors | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | 0.471 |
| GPR143 | GPR108 | ENSP00000417161 | ENSP00000264080 | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport; 7TM orphan receptors | G protein-coupled receptor 108; 7TM orphan receptors | 0.485 |
