FH protein (human) - STRING database

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Score

FH

Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily (510 aa)

Predicted Functional Partners:

MDH2

0.997

CS

0.994

SDHC

0.991

SDHB

0.990

SDHD

0.989

SDHA

0.987

MDH1

0.983

ME1

0.967

OGDH

0.963

ME2

0.962

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CS	FH	ENSP00000342056	ENSP00000355518	Citrate synthase, mitochondrial; Citrate synthase	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	0.994
CS	MDH1	ENSP00000342056	ENSP00000438144	Citrate synthase, mitochondrial; Citrate synthase	Malate dehydrogenase, cytoplasmic; Malate dehydrogenase 1; Belongs to the LDH/MDH superfamily. MDH type 2 family	0.986
CS	MDH2	ENSP00000342056	ENSP00000327070	Citrate synthase, mitochondrial; Citrate synthase	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2	0.997
CS	ME1	ENSP00000342056	ENSP00000358719	Citrate synthase, mitochondrial; Citrate synthase	Malic enzyme 1	0.923
CS	ME2	ENSP00000342056	ENSP00000321070	Citrate synthase, mitochondrial; Citrate synthase	NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family	0.901
CS	OGDH	ENSP00000342056	ENSP00000222673	Citrate synthase, mitochondrial; Citrate synthase	2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components- 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	0.929
CS	SDHA	ENSP00000342056	ENSP00000264932	Citrate synthase, mitochondrial; Citrate synthase	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily	0.973
CS	SDHB	ENSP00000342056	ENSP00000364649	Citrate synthase, mitochondrial; Citrate synthase	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.972
CS	SDHC	ENSP00000342056	ENSP00000356953	Citrate synthase, mitochondrial; Citrate synthase	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the cytochrome b560 family	0.712
CS	SDHD	ENSP00000342056	ENSP00000364699	Citrate synthase, mitochondrial; Citrate synthase	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.420
FH	CS	ENSP00000355518	ENSP00000342056	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Citrate synthase, mitochondrial; Citrate synthase	0.994
FH	MDH1	ENSP00000355518	ENSP00000438144	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Malate dehydrogenase, cytoplasmic; Malate dehydrogenase 1; Belongs to the LDH/MDH superfamily. MDH type 2 family	0.983
FH	MDH2	ENSP00000355518	ENSP00000327070	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2	0.997
FH	ME1	ENSP00000355518	ENSP00000358719	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Malic enzyme 1	0.967
FH	ME2	ENSP00000355518	ENSP00000321070	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family	0.962
FH	OGDH	ENSP00000355518	ENSP00000222673	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components- 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	0.963
FH	SDHA	ENSP00000355518	ENSP00000264932	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily	0.987
FH	SDHB	ENSP00000355518	ENSP00000364649	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.990
FH	SDHC	ENSP00000355518	ENSP00000356953	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the cytochrome b560 family	0.991
FH	SDHD	ENSP00000355518	ENSP00000364699	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.989

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