node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP4A | ISLR2 | ENSP00000262623 | ENSP00000355402 | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; ATPase H+/K+ transporting | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | 0.543 |
ISLR2 | ATP4A | ENSP00000355402 | ENSP00000262623 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; ATPase H+/K+ transporting | 0.543 |
ISLR2 | LAPTM4B | ENSP00000355402 | ENSP00000402301 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | 0.803 |
ISLR2 | LPHN1 | ENSP00000355402 | ENSP00000340688 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.685 |
ISLR2 | LPHN2 | ENSP00000355402 | ENSP00000322270 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.685 |
ISLR2 | LPHN3 | ENSP00000355402 | ENSP00000422533 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.685 |
ISLR2 | N4BP2 | ENSP00000355402 | ENSP00000261435 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | 0.746 |
ISLR2 | PDE10A | ENSP00000355402 | ENSP00000438284 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | cAMP and cAMP-inhibited cGMP 3’,5’-cyclic phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition; Phosphodiesterases | 0.621 |
ISLR2 | SLC1A2 | ENSP00000355402 | ENSP00000278379 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Excitatory amino acid transporter 2; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminatin [...] | 0.652 |
ISLR2 | TFAP2D | ENSP00000355402 | ENSP00000008391 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Transcription factor AP-2-delta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity) | 0.545 |
ISLR2 | VASN | ENSP00000355402 | ENSP00000306864 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Vasorin; May act as an inhibitor of TGF-beta signaling | 0.597 |
LAPTM4B | ISLR2 | ENSP00000402301 | ENSP00000355402 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | 0.803 |
LPHN1 | ISLR2 | ENSP00000340688 | ENSP00000355402 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | 0.685 |
LPHN1 | VASN | ENSP00000340688 | ENSP00000306864 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Vasorin; May act as an inhibitor of TGF-beta signaling | 0.685 |
LPHN2 | ISLR2 | ENSP00000322270 | ENSP00000355402 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | 0.685 |
LPHN2 | VASN | ENSP00000322270 | ENSP00000306864 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Vasorin; May act as an inhibitor of TGF-beta signaling | 0.685 |
LPHN3 | ISLR2 | ENSP00000422533 | ENSP00000355402 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | 0.685 |
LPHN3 | VASN | ENSP00000422533 | ENSP00000306864 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Vasorin; May act as an inhibitor of TGF-beta signaling | 0.685 |
N4BP2 | ISLR2 | ENSP00000261435 | ENSP00000355402 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | 0.746 |
N4BP2 | PDE10A | ENSP00000261435 | ENSP00000438284 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | cAMP and cAMP-inhibited cGMP 3’,5’-cyclic phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition; Phosphodiesterases | 0.637 |