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STRINGSTRING
MED16 MED16 CH25H CH25H C19orf24 C19orf24 SQLE SQLE R3HDM4 R3HDM4 FDFT1 FDFT1 ODF3L2 ODF3L2 LSS LSS C14orf1 C14orf1 MSMO1 MSMO1 FAXDC2 FAXDC2
"R3HDM4" - R3H domain containing 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
R3HDM4R3H domain containing 4 (268 aa)    
Predicted Functional Partners:
LSS
Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency; Belongs to the terpene cyclase/mutase family (732 aa)
      
 
  0.787
FDFT1
Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 (417 aa)
      
 
  0.737
SQLE
Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family (574 aa)
      
   
  0.731
C14orf1
Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family (140 aa)
      
 
  0.716
C19orf24
Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 (132 aa)
            
  0.634
CH25H
Cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues- 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element [...] (272 aa)
      
 
  0.610
FAXDC2
Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family (333 aa)
      
 
  0.610
MSMO1
Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family (293 aa)
      
 
  0.610
ODF3L2
Outer dense fiber of sperm tails 3 like 2 (289 aa)
            
  0.587
MED16
Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (877 aa)
      
   
  0.572
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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