| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD34B | FAM110B | ENSP00000339802 | ENSP00000355204 | Ankyrin repeat domain-containing protein 34B; Ankyrin repeat domain containing; Belongs to the ANKRD34 family | Protein FAM110B; May be involved in tumor progression | 0.741 |
| CHCHD7 | FAM110B | ENSP00000306425 | ENSP00000355204 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | Protein FAM110B; May be involved in tumor progression | 0.551 |
| CHCHD7 | SDR16C5 | ENSP00000306425 | ENSP00000307607 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.799 |
| CSNK1D | CSNK1E | ENSP00000324464 | ENSP00000380044 | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | 0.981 |
| CSNK1D | FAM110B | ENSP00000324464 | ENSP00000355204 | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | Protein FAM110B; May be involved in tumor progression | 0.820 |
| CSNK1E | CSNK1D | ENSP00000380044 | ENSP00000324464 | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.981 |
| CSNK1E | FAM110B | ENSP00000380044 | ENSP00000355204 | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | Protein FAM110B; May be involved in tumor progression | 0.726 |
| CSPP1 | FAM110B | ENSP00000262210 | ENSP00000355204 | Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization | Protein FAM110B; May be involved in tumor progression | 0.930 |
| FAM110B | ANKRD34B | ENSP00000355204 | ENSP00000339802 | Protein FAM110B; May be involved in tumor progression | Ankyrin repeat domain-containing protein 34B; Ankyrin repeat domain containing; Belongs to the ANKRD34 family | 0.741 |
| FAM110B | CHCHD7 | ENSP00000355204 | ENSP00000306425 | Protein FAM110B; May be involved in tumor progression | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family | 0.551 |
| FAM110B | CSNK1D | ENSP00000355204 | ENSP00000324464 | Protein FAM110B; May be involved in tumor progression | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.820 |
| FAM110B | CSNK1E | ENSP00000355204 | ENSP00000380044 | Protein FAM110B; May be involved in tumor progression | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation | 0.726 |
| FAM110B | CSPP1 | ENSP00000355204 | ENSP00000262210 | Protein FAM110B; May be involved in tumor progression | Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization | 0.930 |
| FAM110B | GATM | ENSP00000355204 | ENSP00000379895 | Protein FAM110B; May be involved in tumor progression | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis; Belongs to the amidinotransferase family | 0.550 |
| FAM110B | PPM1K | ENSP00000355204 | ENSP00000477341 | Protein FAM110B; May be involved in tumor progression | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development; Belongs to the PP2C family | 0.714 |
| FAM110B | SDR16C5 | ENSP00000355204 | ENSP00000307607 | Protein FAM110B; May be involved in tumor progression | Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.585 |
| FAM110B | TOX | ENSP00000355204 | ENSP00000354842 | Protein FAM110B; May be involved in tumor progression | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.600 |
| FAM110B | UBXN2B | ENSP00000355204 | ENSP00000382507 | Protein FAM110B; May be involved in tumor progression | UBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity; Belongs to the NSFL1C family | 0.631 |
| GATM | FAM110B | ENSP00000379895 | ENSP00000355204 | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis; Belongs to the amidinotransferase family | Protein FAM110B; May be involved in tumor progression | 0.550 |
| GATM | PPM1K | ENSP00000379895 | ENSP00000477341 | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis; Belongs to the amidinotransferase family | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development; Belongs to the PP2C family | 0.537 |
