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  • 11.0 [archived version]
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COL19A1 COL19A1 VGLL3 VGLL3 TSPYL4 TSPYL4 GABRD GABRD PPP1R32 PPP1R32 PCDH18 PCDH18 FAM222A FAM222A DAB1 DAB1 C7orf57 C7orf57 C3orf58 C3orf58 LRIG3 LRIG3
"PCDH18" - Protocadherin-18 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
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[Homology]
Score
PCDH18Protocadherin-18; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins (1135 aa)    
Predicted Functional Partners:
C3orf58
Deleted in autism protein 1; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIA1 family (430 aa)
           
  0.748
GABRD
Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits (452 aa)
           
  0.531
DAB1
Disabled homolog 1; Adapter molecule functioning in neural development. May regulate SIAH1 activity (555 aa)
     
 
  0.519
C7orf57
Uncharacterized protein C7orf57; Chromosome 7 open reading frame 57 (295 aa)
           
  0.507
PPP1R32
Protein phosphatase 1 regulatory subunit 32 (425 aa)
           
  0.502
LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity); I-set domain containing (1119 aa)
     
   
  0.502
FAM222A
Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family (452 aa)
           
  0.499
COL19A1
Collagen alpha-1(XIX) chain; May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family (1142 aa)
           
  0.496
VGLL3
Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs; Vestigial like family (326 aa)
     
 
  0.477
TSPYL4
Testis-specific Y-encoded-like protein 4; TSPY like 4 (414 aa)
           
  0.447
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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