| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD13D | FAM189B | ENSP00000427130 | ENSP00000354958 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Protein FAM189B; Family with sequence similarity 189 member B | 0.539 |
| BTN2A2 | FAM189B | ENSP00000349143 | ENSP00000354958 | Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family | Protein FAM189B; Family with sequence similarity 189 member B | 0.524 |
| DTNA | FAM189B | ENSP00000470152 | ENSP00000354958 | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors; Belongs to the dystrophin family. Dystrobrevin subfamily | Protein FAM189B; Family with sequence similarity 189 member B | 0.536 |
| FAM189A2 | FAM189B | ENSP00000257515 | ENSP00000354958 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Protein FAM189B; Family with sequence similarity 189 member B | 0.521 |
| FAM189B | ANKRD13D | ENSP00000354958 | ENSP00000427130 | Protein FAM189B; Family with sequence similarity 189 member B | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.539 |
| FAM189B | BTN2A2 | ENSP00000354958 | ENSP00000349143 | Protein FAM189B; Family with sequence similarity 189 member B | Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.524 |
| FAM189B | DTNA | ENSP00000354958 | ENSP00000470152 | Protein FAM189B; Family with sequence similarity 189 member B | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors; Belongs to the dystrophin family. Dystrobrevin subfamily | 0.536 |
| FAM189B | FAM189A2 | ENSP00000354958 | ENSP00000257515 | Protein FAM189B; Family with sequence similarity 189 member B | Protein FAM189A2; Family with sequence similarity 189 member A2 | 0.521 |
| FAM189B | THBS3 | ENSP00000354958 | ENSP00000357362 | Protein FAM189B; Family with sequence similarity 189 member B | Thrombospondin-3; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen | 0.569 |
| FAM189B | TM4SF19 | ENSP00000354958 | ENSP00000273695 | Protein FAM189B; Family with sequence similarity 189 member B | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | 0.473 |
| FAM189B | TMEM179B | ENSP00000354958 | ENSP00000333697 | Protein FAM189B; Family with sequence similarity 189 member B | Transmembrane protein 179B; Belongs to the TMEM179 family | 0.481 |
| FAM189B | TMEM212 | ENSP00000354958 | ENSP00000334072 | Protein FAM189B; Family with sequence similarity 189 member B | Transmembrane protein 212 | 0.556 |
| FAM189B | WWOX | ENSP00000354958 | ENSP00000457230 | Protein FAM189B; Family with sequence similarity 189 member B | WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm; Short chain dehydrogenase/reductase superfamily | 0.533 |
| FAM189B | ZNF195 | ENSP00000354958 | ENSP00000382511 | Protein FAM189B; Family with sequence similarity 189 member B | Zinc finger protein 195; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.557 |
| THBS3 | FAM189B | ENSP00000357362 | ENSP00000354958 | Thrombospondin-3; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen | Protein FAM189B; Family with sequence similarity 189 member B | 0.569 |
| TM4SF19 | FAM189B | ENSP00000273695 | ENSP00000354958 | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | Protein FAM189B; Family with sequence similarity 189 member B | 0.473 |
| TM4SF19 | TMEM212 | ENSP00000273695 | ENSP00000334072 | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | Transmembrane protein 212 | 0.441 |
| TMEM179B | FAM189B | ENSP00000333697 | ENSP00000354958 | Transmembrane protein 179B; Belongs to the TMEM179 family | Protein FAM189B; Family with sequence similarity 189 member B | 0.481 |
| TMEM179B | TMEM212 | ENSP00000333697 | ENSP00000334072 | Transmembrane protein 179B; Belongs to the TMEM179 family | Transmembrane protein 212 | 0.400 |
| TMEM212 | FAM189B | ENSP00000334072 | ENSP00000354958 | Transmembrane protein 212 | Protein FAM189B; Family with sequence similarity 189 member B | 0.556 |
