| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C4orf45 | FNIP2 | ENSP00000412215 | ENSP00000264433 | Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45 | Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; DENN/MADD domain containing | 0.716 |
| C4orf45 | VEPH1 | ENSP00000412215 | ENSP00000354919 | Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45 | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.691 |
| FNIP2 | C4orf45 | ENSP00000264433 | ENSP00000412215 | Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; DENN/MADD domain containing | Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45 | 0.716 |
| FNIP2 | VEPH1 | ENSP00000264433 | ENSP00000354919 | Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; DENN/MADD domain containing | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.546 |
| LRRC4 | VEPH1 | ENSP00000249363 | ENSP00000354919 | Leucine-rich repeat-containing protein 4; Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity); I-set domain containing | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.539 |
| PIGK | SCRG1 | ENSP00000359848 | ENSP00000296506 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein; Belongs to the peptidase C13 family | Scrapie-responsive protein 1; Stimulator of chondrogenesis 1 | 0.639 |
| PIGK | TNFRSF19 | ENSP00000359848 | ENSP00000371693 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein; Belongs to the peptidase C13 family | Tumor necrosis factor receptor superfamily member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death; Tumor necrosis factor receptor superfamily | 0.571 |
| PIGK | VEPH1 | ENSP00000359848 | ENSP00000354919 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein; Belongs to the peptidase C13 family | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.668 |
| PIGK | ZDHHC17 | ENSP00000359848 | ENSP00000403397 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein; Belongs to the peptidase C13 family | Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport; Ankyrin repeat domain containing | 0.709 |
| RASA4B | TEKT5 | ENSP00000440982 | ENSP00000283025 | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.549 |
| RASA4B | VEPH1 | ENSP00000440982 | ENSP00000354919 | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.572 |
| SCRG1 | PIGK | ENSP00000296506 | ENSP00000359848 | Scrapie-responsive protein 1; Stimulator of chondrogenesis 1 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein; Belongs to the peptidase C13 family | 0.639 |
| SCRG1 | VEPH1 | ENSP00000296506 | ENSP00000354919 | Scrapie-responsive protein 1; Stimulator of chondrogenesis 1 | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.564 |
| SCRG1 | ZDHHC17 | ENSP00000296506 | ENSP00000403397 | Scrapie-responsive protein 1; Stimulator of chondrogenesis 1 | Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport; Ankyrin repeat domain containing | 0.612 |
| SLC33A1 | VEPH1 | ENSP00000376587 | ENSP00000354919 | Acetyl-coenzyme A transporter 1; Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides. Negatively regulates BMP signaling; Solute carriers | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.514 |
| TEKT5 | RASA4B | ENSP00000283025 | ENSP00000440982 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | 0.549 |
| TEKT5 | VEPH1 | ENSP00000283025 | ENSP00000354919 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.503 |
| TNFRSF19 | PIGK | ENSP00000371693 | ENSP00000359848 | Tumor necrosis factor receptor superfamily member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death; Tumor necrosis factor receptor superfamily | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein; Belongs to the peptidase C13 family | 0.571 |
| TNFRSF19 | VEPH1 | ENSP00000371693 | ENSP00000354919 | Tumor necrosis factor receptor superfamily member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death; Tumor necrosis factor receptor superfamily | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.594 |
| TNFRSF19 | ZDHHC17 | ENSP00000371693 | ENSP00000403397 | Tumor necrosis factor receptor superfamily member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death; Tumor necrosis factor receptor superfamily | Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport; Ankyrin repeat domain containing | 0.518 |
