node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CST9L | FAM163A | ENSP00000366178 | ENSP00000354891 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | 0.571 |
CST9L | NT5DC2 | ENSP00000366178 | ENSP00000406933 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 5’-nucleotidase domain containing 2 | 0.510 |
CST9L | SPSB2 | ENSP00000366178 | ENSP00000428338 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | SPRY domain-containing SOCS box protein 2; Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.463 |
CST9L | WDR60 | ENSP00000366178 | ENSP00000384290 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | WD repeat-containing protein 60; May play a role in ciliogenesis; WD repeat domain containing | 0.446 |
FAM163A | CST9L | ENSP00000354891 | ENSP00000366178 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.571 |
FAM163A | NEK7 | ENSP00000354891 | ENSP00000356355 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | 0.735 |
FAM163A | NT5DC2 | ENSP00000354891 | ENSP00000406933 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | 5’-nucleotidase domain containing 2 | 0.491 |
FAM163A | RGS1 | ENSP00000354891 | ENSP00000356429 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form | 0.556 |
FAM163A | RGS2 | ENSP00000354891 | ENSP00000235382 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, ther [...] | 0.524 |
FAM163A | RGS21 | ENSP00000354891 | ENSP00000428343 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | Regulator of G-protein signaling 21; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form; Regulators of G-protein signaling | 0.571 |
FAM163A | SPSB2 | ENSP00000354891 | ENSP00000428338 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | SPRY domain-containing SOCS box protein 2; Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.446 |
FAM163A | TOR1AIP2 | ENSP00000354891 | ENSP00000356584 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity; Belongs to the TOR1AIP family | 0.442 |
FAM163A | WDR60 | ENSP00000354891 | ENSP00000384290 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | WD repeat-containing protein 60; May play a role in ciliogenesis; WD repeat domain containing | 0.441 |
FAM163A | ZNF648 | ENSP00000354891 | ENSP00000344129 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | Zinc finger protein 648; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.480 |
NEK7 | FAM163A | ENSP00000356355 | ENSP00000354891 | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | 0.735 |
NEK7 | RGS1 | ENSP00000356355 | ENSP00000356429 | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form | 0.468 |
NEK7 | RGS2 | ENSP00000356355 | ENSP00000235382 | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, ther [...] | 0.555 |
NEK7 | ZNF648 | ENSP00000356355 | ENSP00000344129 | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | Zinc finger protein 648; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.421 |
NT5DC2 | CST9L | ENSP00000406933 | ENSP00000366178 | 5’-nucleotidase domain containing 2 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.510 |
NT5DC2 | FAM163A | ENSP00000406933 | ENSP00000354891 | 5’-nucleotidase domain containing 2 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | 0.491 |