| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDKN1A | RASSF9 | ENSP00000384849 | ENSP00000354884 | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 fo [...] | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.456 |
| NPIPB7 | RASSF9 | ENSP00000415207 | ENSP00000354884 | Nuclear pore complex interacting protein family member B7 | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.519 |
| OCEL1 | RASSF9 | ENSP00000215061 | ENSP00000354884 | occludin/ELL domain containing 1; Belongs to the ELL/occludin family | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.473 |
| PAM | RASSF9 | ENSP00000306100 | ENSP00000354884 | Peptidyl-glycine alpha-amidating monooxygenase; Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.799 |
| RAB11A | RASSF9 | ENSP00000261890 | ENSP00000354884 | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. T [...] | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.713 |
| RASSF2 | RASSF3 | ENSP00000368710 | ENSP00000443021 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain family member 3 | 0.632 |
| RASSF2 | RASSF4 | ENSP00000368710 | ENSP00000339692 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.814 |
| RASSF2 | RASSF7 | ENSP00000368710 | ENSP00000380713 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization; Ras association domain family | 0.813 |
| RASSF2 | RASSF9 | ENSP00000368710 | ENSP00000354884 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.527 |
| RASSF3 | RASSF2 | ENSP00000443021 | ENSP00000368710 | Ras association domain family member 3 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | 0.632 |
| RASSF3 | RASSF4 | ENSP00000443021 | ENSP00000339692 | Ras association domain family member 3 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.614 |
| RASSF3 | RASSF6 | ENSP00000443021 | ENSP00000340578 | Ras association domain family member 3 | Ras association domain-containing protein 6; Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity); Ras association domain family | 0.657 |
| RASSF3 | RASSF7 | ENSP00000443021 | ENSP00000380713 | Ras association domain family member 3 | Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization; Ras association domain family | 0.706 |
| RASSF3 | RASSF9 | ENSP00000443021 | ENSP00000354884 | Ras association domain family member 3 | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.615 |
| RASSF4 | RASSF2 | ENSP00000339692 | ENSP00000368710 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | 0.814 |
| RASSF4 | RASSF3 | ENSP00000339692 | ENSP00000443021 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | Ras association domain family member 3 | 0.614 |
| RASSF4 | RASSF7 | ENSP00000339692 | ENSP00000380713 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization; Ras association domain family | 0.679 |
| RASSF4 | RASSF9 | ENSP00000339692 | ENSP00000354884 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family | 0.468 |
| RASSF6 | RASSF3 | ENSP00000340578 | ENSP00000443021 | Ras association domain-containing protein 6; Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity); Ras association domain family | Ras association domain family member 3 | 0.657 |
| RASSF6 | RASSF7 | ENSP00000340578 | ENSP00000380713 | Ras association domain-containing protein 6; Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity); Ras association domain family | Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization; Ras association domain family | 0.798 |
