| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CA8 | TOX | ENSP00000314407 | ENSP00000354842 | Carbonic anhydrase-related protein; Does not have a carbonic anhydrase catalytic activity | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.622 |
| ETS1 | GATA3 | ENSP00000376436 | ENSP00000368632 | Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | 0.744 |
| ETS1 | TOX | ENSP00000376436 | ENSP00000354842 | Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.570 |
| FAM110B | TOX | ENSP00000355204 | ENSP00000354842 | Protein FAM110B; May be involved in tumor progression | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.600 |
| GATA3 | ETS1 | ENSP00000368632 | ENSP00000376436 | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion | 0.744 |
| GATA3 | TOX | ENSP00000368632 | ENSP00000354842 | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.545 |
| GATA3 | ZBTB7B | ENSP00000368632 | ENSP00000406286 | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | Zinc finger and BTB domain-containing protein 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as [...] | 0.873 |
| NAGLU | SPINT1 | ENSP00000225927 | ENSP00000342098 | Alpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate | Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.626 |
| NAGLU | TOX | ENSP00000225927 | ENSP00000354842 | Alpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.621 |
| SLC25A6 | TOX | ENSP00000370808 | ENSP00000354842 | ADP/ATP translocase 3; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis; Belongs to the mitochondrial carrier (TC 2.A.29) family | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.757 |
| SPINT1 | NAGLU | ENSP00000342098 | ENSP00000225927 | Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | Alpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate | 0.626 |
| SPINT1 | TOX | ENSP00000342098 | ENSP00000354842 | Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.626 |
| TOX | CA8 | ENSP00000354842 | ENSP00000314407 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Carbonic anhydrase-related protein; Does not have a carbonic anhydrase catalytic activity | 0.622 |
| TOX | ETS1 | ENSP00000354842 | ENSP00000376436 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion | 0.570 |
| TOX | FAM110B | ENSP00000354842 | ENSP00000355204 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Protein FAM110B; May be involved in tumor progression | 0.600 |
| TOX | GATA3 | ENSP00000354842 | ENSP00000368632 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | 0.545 |
| TOX | NAGLU | ENSP00000354842 | ENSP00000225927 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Alpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate | 0.621 |
| TOX | SLC25A6 | ENSP00000354842 | ENSP00000370808 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | ADP/ATP translocase 3; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.757 |
| TOX | SPINT1 | ENSP00000354842 | ENSP00000342098 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.626 |
| TOX | TOX2 | ENSP00000354842 | ENSP00000344724 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.708 |
