• Version:
  • 11.0 [archived version]
STRINGSTRING
LACC1 LACC1 CCDC122 CCDC122 SEL1L3 SEL1L3 SLC35E1 SLC35E1 TRIM13 TRIM13 SPRYD7 SPRYD7 LRRC29 LRRC29 KCNRG KCNRG GFOD2 GFOD2 EBPL EBPL KLHL32 KLHL32
"SPRYD7" - SPRY domain containing 7 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRYD7SPRY domain containing 7 (196 aa)    
Predicted Functional Partners:
TRIM13
E3 ubiquitin-protein ligase TRIM13; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor; Belon [...] (410 aa)
     
   
  0.777
KCNRG
Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (272 aa)
           
  0.757
CCDC122
Coiled-coil domain containing 122 (273 aa)
           
  0.624
LACC1
Laccase domain-containing protein 1; Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis; Belongs to the LACC1 family (430 aa)
           
  0.624
EBPL
Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands (206 aa)
           
  0.588
LRRC29
Leucine-rich repeat-containing protein 29; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (223 aa)
           
  0.563
SEL1L3
Protein sel-1 homolog 3; SEL1L family member 3 (1132 aa)
     
   
  0.563
KLHL32
Kelch-like protein 32; Kelch like family member 32; BTB domain containing (620 aa)
           
  0.548
GFOD2
Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly (385 aa)
           
  0.543
SLC35E1
Solute carrier family 35 member E1; Putative transporter; Solute carriers (410 aa)
           
  0.534
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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