node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C12orf74 | C1orf204 | ENSP00000380933 | ENSP00000357082 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | 0.578 |
C12orf74 | FBXL16 | ENSP00000380933 | ENSP00000380746 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.586 |
C12orf74 | LYPD6B | ENSP00000380933 | ENSP00000387077 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing | 0.571 |
C12orf74 | TAS2R3 | ENSP00000380933 | ENSP00000247879 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | Taste receptor type 2 member 3; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 | 0.570 |
C12orf74 | VSIG8 | ENSP00000380933 | ENSP00000357080 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | V-set and immunoglobulin domain containing 8; IgCAM CXADR-related subfamily | 0.572 |
C12orf74 | ZNF485 | ENSP00000380933 | ENSP00000354694 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | Zinc finger protein 485; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.671 |
C1orf204 | C12orf74 | ENSP00000357082 | ENSP00000380933 | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | 0.578 |
C1orf204 | FBXL16 | ENSP00000357082 | ENSP00000380746 | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.485 |
C1orf204 | LYPD6B | ENSP00000357082 | ENSP00000387077 | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing | 0.490 |
C1orf204 | TAS2R3 | ENSP00000357082 | ENSP00000247879 | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | Taste receptor type 2 member 3; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 | 0.435 |
C1orf204 | ZNF485 | ENSP00000357082 | ENSP00000354694 | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | Zinc finger protein 485; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.497 |
FBXL16 | C12orf74 | ENSP00000380746 | ENSP00000380933 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | 0.586 |
FBXL16 | C1orf204 | ENSP00000380746 | ENSP00000357082 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | 0.485 |
FBXL16 | LYPD6B | ENSP00000380746 | ENSP00000387077 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing | 0.493 |
FBXL16 | TAS2R3 | ENSP00000380746 | ENSP00000247879 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Taste receptor type 2 member 3; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 | 0.427 |
FBXL16 | VSIG8 | ENSP00000380746 | ENSP00000357080 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | V-set and immunoglobulin domain containing 8; IgCAM CXADR-related subfamily | 0.478 |
FBXL16 | ZNF485 | ENSP00000380746 | ENSP00000354694 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Zinc finger protein 485; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.535 |
LYPD6B | C12orf74 | ENSP00000387077 | ENSP00000380933 | Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | 0.571 |
LYPD6B | C1orf204 | ENSP00000387077 | ENSP00000357082 | Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 | 0.490 |
LYPD6B | FBXL16 | ENSP00000387077 | ENSP00000380746 | Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.493 |