MAGEC2 protein (human) - STRING database

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MAGEC2

Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family (373 aa)

Predicted Functional Partners:

PASD1

0.843

SAGE1

0.828

MAGEC1

0.790

TRIM28

0.774

SSX2

0.749

CRK

0.733

SPA17

0.732

SSX1

0.708

CTAG1B

0.686

CTAG1A

0.685

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRK	MAGEC2	ENSP00000300574	ENSP00000354660	Adapter molecule crk; Isoform Crk-II- Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling	Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family	0.733
CTAG1A	CTAG1B	ENSP00000469441	ENSP00000332602	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	0.793
CTAG1A	MAGEC1	ENSP00000469441	ENSP00000285879	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Melanoma-associated antigen C1; MAGE family member C1	0.845
CTAG1A	MAGEC2	ENSP00000469441	ENSP00000354660	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family	0.685
CTAG1A	PASD1	ENSP00000469441	ENSP00000359382	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed	0.550
CTAG1A	SAGE1	ENSP00000469441	ENSP00000323191	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Sarcoma antigen 1	0.457
CTAG1A	SSX1	ENSP00000469441	ENSP00000366118	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family	0.670
CTAG1A	SSX2	ENSP00000469441	ENSP00000338796	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Synovial sarcoma, X breakpoint 2; SSX family member 2	0.797
CTAG1B	CTAG1A	ENSP00000332602	ENSP00000469441	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	0.793
CTAG1B	MAGEC1	ENSP00000332602	ENSP00000285879	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	Melanoma-associated antigen C1; MAGE family member C1	0.858
CTAG1B	MAGEC2	ENSP00000332602	ENSP00000354660	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family	0.686
CTAG1B	PASD1	ENSP00000332602	ENSP00000359382	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed	0.551
CTAG1B	SAGE1	ENSP00000332602	ENSP00000323191	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	Sarcoma antigen 1	0.468
CTAG1B	SSX1	ENSP00000332602	ENSP00000366118	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family	0.670
CTAG1B	SSX2	ENSP00000332602	ENSP00000338796	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	Synovial sarcoma, X breakpoint 2; SSX family member 2	0.797
MAGEC1	CTAG1A	ENSP00000285879	ENSP00000469441	Melanoma-associated antigen C1; MAGE family member C1	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	0.845
MAGEC1	CTAG1B	ENSP00000285879	ENSP00000332602	Melanoma-associated antigen C1; MAGE family member C1	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	0.858
MAGEC1	MAGEC2	ENSP00000285879	ENSP00000354660	Melanoma-associated antigen C1; MAGE family member C1	Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family	0.790
MAGEC1	PASD1	ENSP00000285879	ENSP00000359382	Melanoma-associated antigen C1; MAGE family member C1	Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed	0.891
MAGEC1	SAGE1	ENSP00000285879	ENSP00000323191	Melanoma-associated antigen C1; MAGE family member C1	Sarcoma antigen 1	0.758

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