node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CADPS2 | RUNDC1 | ENSP00000398481 | ENSP00000354622 | Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity); C2 domain containing | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | 0.620 |
CCDC132 | CCDC186 | ENSP00000307666 | ENSP00000358293 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) | Coiled-coil domain containing 186 | 0.487 |
CCDC132 | RUNDC1 | ENSP00000307666 | ENSP00000354622 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | 0.673 |
CCDC132 | TSSC1 | ENSP00000307666 | ENSP00000371559 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) | EARP-interacting protein; Tumor suppressing subtransferable candidate 1 | 0.949 |
CCDC132 | VPS51 | ENSP00000307666 | ENSP00000279281 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) | Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex [...] | 0.999 |
CCDC186 | CCDC132 | ENSP00000358293 | ENSP00000307666 | Coiled-coil domain containing 186 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) | 0.487 |
CCDC186 | RAB2B | ENSP00000358293 | ENSP00000380869 | Coiled-coil domain containing 186 | Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases | 0.536 |
CCDC186 | RUNDC1 | ENSP00000358293 | ENSP00000354622 | Coiled-coil domain containing 186 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | 0.678 |
CCDC186 | TSSC1 | ENSP00000358293 | ENSP00000371559 | Coiled-coil domain containing 186 | EARP-interacting protein; Tumor suppressing subtransferable candidate 1 | 0.493 |
RAB2B | CCDC186 | ENSP00000380869 | ENSP00000358293 | Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases | Coiled-coil domain containing 186 | 0.536 |
RAB2B | RUNDC1 | ENSP00000380869 | ENSP00000354622 | Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | 0.527 |
RUNDC1 | CADPS2 | ENSP00000354622 | ENSP00000398481 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity); C2 domain containing | 0.620 |
RUNDC1 | CCDC132 | ENSP00000354622 | ENSP00000307666 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) | 0.673 |
RUNDC1 | CCDC186 | ENSP00000354622 | ENSP00000358293 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | Coiled-coil domain containing 186 | 0.678 |
RUNDC1 | RAB2B | ENSP00000354622 | ENSP00000380869 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases | 0.527 |
RUNDC1 | TAF5 | ENSP00000354622 | ENSP00000358854 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | Transcription initiation factor TFIID subunit 5; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TA [...] | 0.572 |
RUNDC1 | TNFAIP1 | ENSP00000354622 | ENSP00000226225 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity; Belongs to the BACURD family | 0.563 |
RUNDC1 | TSSC1 | ENSP00000354622 | ENSP00000371559 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | EARP-interacting protein; Tumor suppressing subtransferable candidate 1 | 0.656 |
RUNDC1 | TTC25 | ENSP00000354622 | ENSP00000478589 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility; Tetratricopeptide repeat domain containing | 0.523 |
RUNDC1 | VPS51 | ENSP00000354622 | ENSP00000279281 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity | Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex [...] | 0.533 |