GPX6 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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some 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Score

GPX6

Glutathione peroxidase 6; Selenoproteins (221 aa)

Predicted Functional Partners:

SOD1

0.966

SOD2

0.961

SOD3

0.955

GSS

0.944

ALOX5

0.909

CAT

0.880

GSR

0.869

GSTM3

0.866

GSTM2

0.866

HPGDS

0.826

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALOX5	GPX6	ENSP00000363512	ENSP00000354581	Arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes; Belongs to the lipoxygenase family	Glutathione peroxidase 6; Selenoproteins	0.909
CAT	GPX6	ENSP00000241052	ENSP00000354581	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Glutathione peroxidase 6; Selenoproteins	0.880
CAT	GSR	ENSP00000241052	ENSP00000221130	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol	0.987
CAT	GSS	ENSP00000241052	ENSP00000216951	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Glutathione synthetase; Belongs to the eukaryotic GSH synthase family	0.890
CAT	GSTM2	ENSP00000241052	ENSP00000241337	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family	0.654
CAT	GSTM3	ENSP00000241052	ENSP00000256594	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Glutathione S-transferase Mu 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers; Belongs to the GST superfamily. Mu family	0.695
CAT	HPGDS	ENSP00000241052	ENSP00000295256	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide; Belongs to the GST superfamily. Sigma family	0.924
CAT	SOD1	ENSP00000241052	ENSP00000270142	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems	0.996
CAT	SOD2	ENSP00000241052	ENSP00000446252	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems	0.998
CAT	SOD3	ENSP00000241052	ENSP00000371554	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen	0.989
GPX6	ALOX5	ENSP00000354581	ENSP00000363512	Glutathione peroxidase 6; Selenoproteins	Arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes; Belongs to the lipoxygenase family	0.909
GPX6	CAT	ENSP00000354581	ENSP00000241052	Glutathione peroxidase 6; Selenoproteins	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family	0.880
GPX6	GSR	ENSP00000354581	ENSP00000221130	Glutathione peroxidase 6; Selenoproteins	Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol	0.869
GPX6	GSS	ENSP00000354581	ENSP00000216951	Glutathione peroxidase 6; Selenoproteins	Glutathione synthetase; Belongs to the eukaryotic GSH synthase family	0.944
GPX6	GSTM2	ENSP00000354581	ENSP00000241337	Glutathione peroxidase 6; Selenoproteins	Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family	0.866
GPX6	GSTM3	ENSP00000354581	ENSP00000256594	Glutathione peroxidase 6; Selenoproteins	Glutathione S-transferase Mu 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers; Belongs to the GST superfamily. Mu family	0.866
GPX6	HPGDS	ENSP00000354581	ENSP00000295256	Glutathione peroxidase 6; Selenoproteins	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide; Belongs to the GST superfamily. Sigma family	0.826
GPX6	SOD1	ENSP00000354581	ENSP00000270142	Glutathione peroxidase 6; Selenoproteins	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems	0.966
GPX6	SOD2	ENSP00000354581	ENSP00000446252	Glutathione peroxidase 6; Selenoproteins	Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems	0.961
GPX6	SOD3	ENSP00000354581	ENSP00000371554	Glutathione peroxidase 6; Selenoproteins	Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen	0.955

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