node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCYAP1 | C1orf85 | ENSP00000462647 | ENSP00000354553 | Pituitary adenylate cyclase-activating polypeptide; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity); Belongs to the glucagon family | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | 0.471 |
ADD3 | C1orf85 | ENSP00000348381 | ENSP00000354553 | Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldolase class II family. Adducin subfamily | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | 0.632 |
C1orf85 | ADCYAP1 | ENSP00000354553 | ENSP00000462647 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Pituitary adenylate cyclase-activating polypeptide; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity); Belongs to the glucagon family | 0.471 |
C1orf85 | ADD3 | ENSP00000354553 | ENSP00000348381 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldolase class II family. Adducin subfamily | 0.632 |
C1orf85 | CACYBP | ENSP00000354553 | ENSP00000356652 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) | 0.708 |
C1orf85 | CEP85 | ENSP00000354553 | ENSP00000252992 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | 0.521 |
C1orf85 | CTNNB1 | ENSP00000354553 | ENSP00000344456 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.690 |
C1orf85 | FCF1 | ENSP00000354553 | ENSP00000344393 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | 0.644 |
C1orf85 | LINS | ENSP00000354553 | ENSP00000318423 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Lines homolog (Drosophila) | 0.550 |
C1orf85 | RNF222 | ENSP00000354553 | ENSP00000382330 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Ring finger protein 222 | 0.475 |
C1orf85 | TMEM208 | ENSP00000354553 | ENSP00000305892 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy | 0.463 |
C1orf85 | YBX3 | ENSP00000354553 | ENSP00000228251 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | Y-box-binding protein 3; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity); Y box binding proteins | 0.563 |
CACYBP | C1orf85 | ENSP00000356652 | ENSP00000354553 | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | 0.708 |
CACYBP | CTNNB1 | ENSP00000356652 | ENSP00000344456 | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.948 |
CEP85 | C1orf85 | ENSP00000252992 | ENSP00000354553 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | 0.521 |
CEP85 | TMEM208 | ENSP00000252992 | ENSP00000305892 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy | 0.576 |
CTNNB1 | C1orf85 | ENSP00000344456 | ENSP00000354553 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | 0.690 |
CTNNB1 | CACYBP | ENSP00000344456 | ENSP00000356652 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) | 0.948 |
FCF1 | C1orf85 | ENSP00000344393 | ENSP00000354553 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | 0.644 |
LINS | C1orf85 | ENSP00000318423 | ENSP00000354553 | Lines homolog (Drosophila) | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family | 0.550 |