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RNF222 RNF222 CACYBP CACYBP ADCYAP1 ADCYAP1 CTNNB1 CTNNB1 ADD3 ADD3 C1orf85 C1orf85 TMEM208 TMEM208 CEP85 CEP85 LINS LINS FCF1 FCF1 YBX3 YBX3
"C1orf85" - Glycosylated lysosomal membrane protein in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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C1orf85Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family (406 aa)    
Predicted Functional Partners:
CACYBP
Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (228 aa)
       
      0.708
CTNNB1
Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa)
       
      0.690
FCF1
rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (198 aa)
           
  0.644
ADD3
Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldolase class II family. Adducin subfamily (706 aa)
           
  0.632
YBX3
Y-box-binding protein 3; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity); Y box binding proteins (372 aa)
           
  0.563
LINS
Lines homolog (Drosophila) (757 aa)
           
  0.550
CEP85
Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family (762 aa)
           
  0.521
RNF222
Ring finger protein 222 (220 aa)
           
  0.475
ADCYAP1
Pituitary adenylate cyclase-activating polypeptide; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity); Belongs to the glucagon family (176 aa)
           
  0.471
TMEM208
Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy (173 aa)
     
   
  0.463
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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